About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Exercise Come Handy When Stem Cell Therapy Fails

by Anjali Aryamvally on November 16, 2017 at 1:54 PM
Font : A-A+

Exercise Come Handy When Stem Cell Therapy Fails

Exercise leads to significant improvements in walking ability of patients with peripheral artery disease while a stem cell therapy failed to do so, according to the results of a new Northwestern Medicine clinical trial.

The study published in the Journal of the American Medical Association (JAMA), was led by Dr. Mary McDermott, the Jeremiah Stamler Professor of Medicine at Northwestern University Feinberg School of Medicine, and a Northwestern Medicine physician.

Advertisement


Peripheral artery disease (PAD), which affects up to 20 percent of people older than 60, is a condition in which atherosclerotic blockages in the legs lead to pain or weakness when walking.

There are few effective therapies to prevent mobility loss in people with PAD, although previous research led by McDermott demonstrated that certain exercise interventions can improve walking ability.
Advertisement

"There is a lot of interest in stem cell therapy, and this is the largest trial of this type of therapy conducted to date in people with blockages in their leg arteries," McDermott said. "It was disappointing that we did not see a benefit from this because so few therapies are available for patients with peripheral artery disease, and earlier research suggested this drug may be beneficial. More research is needed to identify new effective therapies."

In the current study, the investigators evaluated whether a stem cell-based therapy called granulocyte-macrophage colony-stimulating factor (GM-CSF), when administrated alone or combined with exercise, would lead to increased distance walked over six minutes.

GM-CSF is a drug designed to increase circulating stem cells in the blood, which had potential for improving walking performance in people with PAD, according to McDermott.

Investigators had also hypothesized that combining the therapy with exercise would further increase the drug's effectiveness.

The team randomized 210 participants with PAD to one of four groups: GM-CSF with exercise, GM-CSF alone, exercise alone (with placebo) or a control that received no active therapies. The exercise consisted of supervised treadmill exercises completed three times weekly for six months. The GM-CSF and the placebo were administered via injection three times a week for the first two weeks of the intervention.

The trial showed that at 12 weeks after the intervention, the drug therapy had not led to improved walking performance, either alone or combined with exercise. Still, the data showed that exercise significantly improved patients' six-minute walking distance, as compared to the control.

"Although this trial showed no added benefit of stem cell mobilization by GM-CSF in individuals with PAD, it yet again confirmed the benefits of exercise on walking capacity that have been observed in previous studies," said Dr. Diane Reid, a National Heart, Lung and Blood Institute (NHLBI) project officer for the study and a medical officer in the NHLBI Vascular Biology and Hypertension Branch. "Prompt reporting of negative clinical trial results, as done here, provides valuable information to guide the future directions of research on potential new therapeutics."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Diet Lifestyle and Heart Disease Reiki and Pranic Healing Tips to Live Longer Exercise and Fitness Lifestyle Modification: No Big Deal! Body Types and Befitting Workouts 

Recommended Reading
Benefits of Aerobic Exercises
Aerobics is a physical exercise that includes activities like dance, cycling, running, stretching .....
Brain Exercises to Improve Memory
An active brain can certainly help in improving memory by strengthening the connections between ......
Back Pain at Workplace: Prevention and Exercises
Understanding the basics about our back and our posture is very important in preventing back pain .....
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces ......
Body Types and Befitting Workouts
Workout and diet which is well suited for a pear shaped body....
Exercise and Fitness
Exercise is about revamping your lifestyle, not just weight loss. Exercise to get healthy – that way...
Lifestyle Modification: No Big Deal!
Simple and practically possible lifestyle changes can make a huge difference in improving our health...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Tips to Live Longer
Though life is temporary and short, it is possible to maximize the span of our existence by living h...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use