Medindia
Advertisement

Inhibiting Membrane Attack Complex Reduces Nerve Damage, Improves Recovery in Leprosy

by Julia Samuel on June 10, 2015 at 11:26 AM
Font : A-A+

Inhibiting Membrane Attack Complex Reduces Nerve Damage, Improves Recovery in Leprosy

Detecting leprosy long before it manifests skin lesions could improve the lives of thousands suffering with leprosy in India.

Mycobacterium leprae, a bacterium, causes leprosy and peripheral nerve damage is the major effect of the disease but its origins had remained unclear until now.

Advertisement

Experts have been exploring the relationship between the bacteria, which causes leprosy, and the formation of the membrane attack complex (MAC), which is a tool deployed by the innate immune system to fight pathogens.

MAC can damage adjacent health tissues and trigger inflammation at the early stages of the disease. However, new research shows that inhibition of MAC formation reduces nerve damage and improves regeneration and functional recovery.
Advertisement

Professor Pranab K. Das, Honorary Senior Research Fellow, University of Birmingham said, "Our new research shows that inflammatory reactions can be prevented at an early stage of the disease, reducing the risk of the nerve damage that leads to the disabilities caused by leprosy. We propose that MAC inhibition could form the basis of the future development of novel therapeutics from leprosy."

It is also suggested that biomarkers could be used to study the mechanism of autonomic neuropathy in general, with the aim of new drug development for autoimmune diseases such as diabetes, rheumatoid arthritis and lupus.

Despite a marked decline in the number of cases of leprosy since the 1980s and effective multidrug therapy (MDT), the disease remains endemic in several countries, including India - where the disease is most prevalent. Almost 135,000 new cases of the disease were reported in India during 2012.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sedentary Behavior Precipitates Night-Time Hot Flashes
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Leprosy Brachial Plexus Injury 

Recommended Reading
Leprosy
Leprosy, caused by Mycobacterium leprae, affects any organ like skin, eyes, mucosa, periphery ......
Indian Government Aims to End Social Stigma Against Leprosy Patients By 2017
Leprosy, also known as Hansen's disease, is a chronic infection caused by bacteria and the affected ...
An Indian State Government Offers Jobs in Health Dept for Leprosy-Cured Persons
The government will consider appointing people, who had undergone long treatments to cure ......
Law Commission Submits Report to Eliminate Discrimination Against Leprosy Patients
The draft bill focuses on non-discrimination, social inclusion and equal protection before the law ....
Brachial Plexus Injury
Brachial plexus is a network of nerves that transmits signals from the spine to shoulder, arm and .....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use