Rahul Kohli, an Indian origin scientist is among the winners of a GlaxoSmithKline (GSK) "academic drug hunter" competition, that will help fast track his lab's work in combating drug-resistant bacteria.
With this new partnership, Rahul Kohli, MD, PhD, an assistant professor in the division of Infectious Diseases and department of Biochemistry and Biophysics at the Perelman School of Medicine at the University of Pennsylvania, and his lab can ramp up their efforts to discover drugs that stop the evolution in its tracks.
New Delhi Multidrug Resistant Bacteria Found in Toronto Hospital
A hospital in Canada detected the presence of New Delhi Metallo-ß-lactamase-1-Producing Klebsiella pneumoniae (NDM1-Kp), as the prevalence of antibiotic-resistant infections continue to rise.
Advertisement
Rather than taking the conventional approach of modifying existing antibiotics to overcome resistance, Kohli's lab aims to target the very pathways by which bacteria adapt to antibiotics and evolve resistance.
Kohli's team, spearheaded by Charlie Mo, a graduate student in Biochemistry and Molecular Biophysics, will now have access to 1.8 million compounds kept in GSK's chemical library and their other drug discovery technologies.
![Study Insists On Improved Approach To Fight Against Drug Resistant Bacteria]( "Study Insists On Improved Approach To Fight Against Drug Resistant Bacteria")
A new study has found that a small molecule composed of one atom of oxygen and one of nitrogen plays an important role in helping pathogens resist antibiotics.
Kohli said that the search is on to find a molecule that can disrupt the pathway that allows bacteria to acquire drug resistance, asserting that the hope is that such a molecule can make bacteria more sensitive to existing antibiotics or slow the acquisition to the resistance, both of which would be valuable in the clinic.
This is GSK's first Discovery Fast Track competition in North America, which is designed to translate academic research into starting points for new potential medicines. There were eight winners in total across the country, selected from an initial pool of over 140 applications across 17 therapeutic areas and from 70 different institutions.
Source: ANI
Study Insists On Improved Approach To Fight Against Drug Resistant Bacteria
A new study has found that a small molecule composed of one atom of oxygen and one of nitrogen plays an important role in helping pathogens resist antibiotics.
Advertisement
Kohli said that the search is on to find a molecule that can disrupt the pathway that allows bacteria to acquire drug resistance, asserting that the hope is that such a molecule can make bacteria more sensitive to existing antibiotics or slow the acquisition to the resistance, both of which would be valuable in the clinic.
This is GSK's first Discovery Fast Track competition in North America, which is designed to translate academic research into starting points for new potential medicines. There were eight winners in total across the country, selected from an initial pool of over 140 applications across 17 therapeutic areas and from 70 different institutions.
Source: ANI
Concern Over Use of Drugs in Animal Feed
Drugs fed to animals to promote growth may lead to the emergence of antibiotic resistant bacteria, say microbiologists.
Advertisement
 New Technique Helps Target Antibiotic-resistant BacteriaScientists have developed a novel method which targets antibiotic resistant bacteria and protects patients from the toxic parts of an antibiotic drug. | Advertisement
|
Advertisement
Recommended Readings
Latest Research News
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance.
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells.
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury.
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
