About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

In Sepsis Patients With ARDS, Statins Fail To Reduce Mortality Rate

by Bidita Debnath on May 21, 2014 at 12:39 AM
Font : A-A+

 In Sepsis Patients With ARDS, Statins Fail To Reduce Mortality Rate

Despite previous observational and basic science evidence suggesting the use of statins may improve outcomes in patients with sepsis and acute respiratory distress syndrome (ARDS), a double-blinded clinical trial of rosuvastatin in those patients was futile.

But the study was halted. The findings are published in the May 18, 2014 New England Journal of Medicine, along with accompanying editorials evaluating the research's goals and outcomes. The primary investigator and lead author of the study is Jonathon D. Truwit, M.D., professor of medicine and enterprise chief medical officer and senior administrative dean at Froedtert & the Medical College of Wisconsin. Despite improvements in supportive care for ARDS, the mortality rate remains high, one in four patients die.

Advertisement

Sepsis is the major reason patients develop ARDS. Statins have been shown to reduce inflammation and prevent ARDS in basic science studies, and have also been reported in observational studies to improve outcomes in patients with sepsis and ARDS. In this study, patients received either the rosuvastatin or a placebo, and the study was double-blinded.

After 745 of the proposed 1000 patients had been enrolled in the multi-center trial, the study was halted because there was no significant difference between the study groups. Further, the rosuvastatin therapy may have contributed to hepatic and renal organ dysfunction. "While this therapy did not lead to better outcomes, it is important that we evaluate possible therapies for conditions such as ARDS because it adds to our knowledge about this condition, which has a high mortality rate for patients. The information gathered in this study will guide further basic and clinical research to ultimately improve our care for critically ill patients," said Dr. Truwit.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol Cholesterol - The Enigma Chemical Statins Septicemia 

Recommended Reading
Custom-Made Mouthguards Reduce Sports-Related Concussion
Parents who want to reduce their child's risk of a sports-related concussion should visit a dentist ...
Gays and Lesbian Teens More Inclined Towards Binge Drinking
According to a study, there has been increase in binge drinking by lesbian and gay adolescents ......
Hardships of Migrant Life in London Confronted Head-On by Polish MP
A Polish MP, who sacrificed his bed for the floor and his corner office for a building site, says .....
Cholesterol
Cholesterol is produced by the body (liver) and is essential for normal body functioning....
Cholesterol - The Enigma Chemical
The word 'Cholesterol' rings danger bells as soon as it is mentioned. This important chemical is im...
Septicemia
Septicemia or sepsis is a serious illness wherein a patient develops symptoms due to presence of mic...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use