Bone homeostasis requires precise balance between resorption of old bone by osteoclasts and deposition of new bone by osteoblasts. Bone diseases, including osteoporosis and rheumatoid arthritis, are the result of increased osteoclast activity and formation, which allows bone resorption to outpace deposition. In this issue of the Journal of Clinical Investigation, Brendan Boyce and colleagues at the University of Rochester evaluated the role of TNF receptor-associated receptor 3 (TRAF3) in promoting osteoclast formation. Mice lacking TRAF3 in osteoclast precursor cells had mild osteoporosis that was associated with increased osteoclast formation. The authors found that chloroquine treatment increased TRAF3 in osteoclast precursor cells and limited osteoclast generation. Furthermore, treatment of mouse models of osteoporosis with chloroquine inhibited osteoclast formation. These studies implicate that therapies aimed at increasing TRAF3 in osteoclast precursor cells may limit bone loss for those with bone diseases. Source: Eurekalert << Inflammation in Prostate may Reduce Risk for Prostate Cance... US to Cut Down on Use of Antibiotics in Farm Animals >> Recommended Reading Research may Explain Fractures in Some Who Take Osteoporosis Drugs At the Texas Biomedical Research Institute, research with baboons may help explain why some people who take bone-strengthening drugs like bisphosphonates are at-risk for atypical fractures in the long bones in their legs. READ MORE Nearly 22 Million Aged Women are Affected by Osteoporosis in the European Union More than 22 million women aged between 50-84 years in the European Union (EU) have osteoporosis, estimates a recent report issued by the International Osteoporosis Foundation (IOF). READ MORE Statin Osteoporosis Drug Combo Could Treat Parasitic Infections A combo of two drugs prescribed for high cholesterol and osteoporosis could be a new treatment for toxoplasmosis, a parasitic infection, researchers found READ MORE Osteoporosis Drug Stops Growth of Breast Cancer Cells A drug used to treat osteoporosis has now been shown to stop the growth of breast cancer cells, finds study. READ MORE Infantile Cortical Hyperostosis Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the cortical bones of infants is the prime finding READ MORE Osteoporosis Osteoporosis is a bone disease that leads to an increased risk of fractures. The bone mass is reduced and the bones are porous, thereby resulting in weakness of the skeletal system of the body. READ MORE Renal Osteodystrophy / Mineral Bone Disorder Renal Osteodystrophy which is referred to as Mineral Bone Disorder is a result of imbalance in calcium, phosphorus, parathyroid hormone and Vitamin D levels. READ MORE Most Popular on Medindia Drug - Food Interactions Drug Interaction Checker Nutam (400mg) (Piracetam) More News on: OsteoporosisInfantile Cortical HyperostosisParkinsons Disease Surgical TreatmentRenal Osteodystrophy / Mineral Bone Disorder
Bone homeostasis requires precise balance between resorption of old bone by osteoclasts and deposition of new bone by osteoblasts. Bone diseases, including osteoporosis and rheumatoid arthritis, are the result of increased osteoclast activity and formation, which allows bone resorption to outpace deposition. In this issue of the Journal of Clinical Investigation, Brendan Boyce and colleagues at the University of Rochester evaluated the role of TNF receptor-associated receptor 3 (TRAF3) in promoting osteoclast formation. Mice lacking TRAF3 in osteoclast precursor cells had mild osteoporosis that was associated with increased osteoclast formation. The authors found that chloroquine treatment increased TRAF3 in osteoclast precursor cells and limited osteoclast generation. Furthermore, treatment of mouse models of osteoporosis with chloroquine inhibited osteoclast formation. These studies implicate that therapies aimed at increasing TRAF3 in osteoclast precursor cells may limit bone loss for those with bone diseases. Source: Eurekalert << Inflammation in Prostate may Reduce Risk for Prostate Cance... US to Cut Down on Use of Antibiotics in Farm Animals >> Recommended Reading Research may Explain Fractures in Some Who Take Osteoporosis Drugs At the Texas Biomedical Research Institute, research with baboons may help explain why some people who take bone-strengthening drugs like bisphosphonates are at-risk for atypical fractures in the long bones in their legs. READ MORE Nearly 22 Million Aged Women are Affected by Osteoporosis in the European Union More than 22 million women aged between 50-84 years in the European Union (EU) have osteoporosis, estimates a recent report issued by the International Osteoporosis Foundation (IOF). READ MORE Statin Osteoporosis Drug Combo Could Treat Parasitic Infections A combo of two drugs prescribed for high cholesterol and osteoporosis could be a new treatment for toxoplasmosis, a parasitic infection, researchers found READ MORE Osteoporosis Drug Stops Growth of Breast Cancer Cells A drug used to treat osteoporosis has now been shown to stop the growth of breast cancer cells, finds study. READ MORE Infantile Cortical Hyperostosis Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the cortical bones of infants is the prime finding READ MORE Osteoporosis Osteoporosis is a bone disease that leads to an increased risk of fractures. The bone mass is reduced and the bones are porous, thereby resulting in weakness of the skeletal system of the body. READ MORE Renal Osteodystrophy / Mineral Bone Disorder Renal Osteodystrophy which is referred to as Mineral Bone Disorder is a result of imbalance in calcium, phosphorus, parathyroid hormone and Vitamin D levels. READ MORE Most Popular on Medindia Drug - Food Interactions Drug Interaction Checker Nutam (400mg) (Piracetam) More News on: OsteoporosisInfantile Cortical HyperostosisParkinsons Disease Surgical TreatmentRenal Osteodystrophy / Mineral Bone Disorder
