About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Impaired Consciousness Found In Epilepsy Patients With Complex Partial Seizures

by Rukmani Krishna on December 12, 2013 at 11:56 PM
Font : A-A+

 Impaired Consciousness Found In Epilepsy Patients With Complex Partial Seizures

Impaired consciousness is seen in epilepsy patients with complex partial seizures during seizure episodes and typically have no memory of the event. However, the mechanisms of seizure unconsciousness are unclear. Research reported today at the American Epilepsy Society (AES) 67th Annual Meeting suggests that the mechanism underlying loss of awareness during complex partial seizures is likely the same as that involved in slow wave or deep sleep.

In earlier research the team of investigators from Yale Medical School revealed an association between slow wave oscillations in neocortex and loss of consciousness in complex partial seizures. They also developed a rodent model with similar seizure characteristics, including neocortical slow waves similar to those seen in sleep. With the use of this model, the team then sought to find whether the slow waves of seizures were closely related to decreased acetylcholine in a specific sleep-associated brain area, as occurs in slow wave sleep. (Platform - Role of Decreased Cholinergic Neurotransmission in Reduced Corticothalamic Arousal during Complex Partial Seizures.)

Advertisement

The synthesis and release of acetylcholine is followed by breakdown into the molecule choline. That molecule was thus used in this study as a proxy for acetylcholine and choline levels at the target site were recorded using an implanted choline-oxidase coated microelectrode.

To determine if there was a reduction in choline levels concordant with decreased neuronal activity, fluctuations in neuronal activity were mapped by functional MRI. When seizures were induced in the animal models, decreases were observed in both fMRI blood oxygen levels and in the microelectrode choline level recordings, demonstrating, for the first time, a drop in cholinergic neurotransmission during limbic seizures in rodents.
Advertisement

"This suggests a possible mechanism to explain the slow oscillations and unconsciousness of complex partial seizures, " says Hal Blumenfeld, M.D., Ph.D., of Yale Medical School, lead investigator on the report. "These seizures propagate from the hippocampus to limbic structures containing inhibitory projection neurons. Neuronal activity in the arousal nuclei of the brainstem and basal forebrain then decreases; and this leads to decreased levels of arousal in the thalamus and cortex, and to impaired consciousness. We hope this research will help save lives of people with epilepsy who are in danger of accidents or breathing difficulty from the deep unconsciousness accompanying seizures."

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Epilepsy Febrile Fits / Febrile Convulsions Neurocysticercosis Reye’s Syndrome Convulsions Decreased Consciousness Fainting Symptom Evaluation Electroencephalogram Aicardi-Goutieres Syndrome Cavernous Malformation 

Recommended Reading
Genetic Causes of Epilepsy-New Facts Revealed
Scientists, while screening the DNA of huge cohorts for epilepsy-associated genes are now finding .....
Aicardi-Goutieres Syndrome
Aicardi-Goutieres Syndrome is observed in infants and older children. To date, defects in 6 genes ar...
Cavernous Malformation
Cavernous malformations are malformations in blood vessels that can cause neurological disorders whe...
Convulsions
Seizure or a convulsion is a result of abnormal electrical activity in the brain. If there are two o...
Decreased Consciousness
Consciousness can be decreased to various degrees and result in conditions like delirium, stupor, co...
Electroencephalogram
An electroencephalogram (EEG) detects electrical activity in the brain using electrodes attached to ...
Epilepsy
Fits or convulsions or Epilepsy is characterized by recurrent, involuntary seizures and is described...
Fainting Symptom Evaluation
Fainting or syncope is characterized by transient loss of consciousness and a spontaneous recovery....
Febrile Fits / Febrile Convulsions
High fever in kids can cause convulsions and are called febrile fits that do not include the seizure...
Neurocysticercosis
Neurocysticercosis or Cysticercosis of brain is the most common cause of epilepsy and the most commo...
Reye’s Syndrome
Reye's syndrome is a medical emergency chiefly affecting children and teenagers and is marked by the...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use