About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

How Western Diet Triggers Amyloid Beta Plaque Formation in the Brain

by Reshma Anand on March 5, 2016 at 12:44 PM
Font : A-A+

How Western Diet Triggers Amyloid Beta Plaque Formation in the Brain

People who eat a western diet and be sedentary may have an increased susceptibility to Alzheimer's disease, said a new study.

In fact, it is estimated that a combination of diet and inactivity contributes to as many as 25% of Alzheimer's cases. Nonetheless, little is known about the exact disease mechanisms and how or why this increasingly common middle-age lifestyle can play such a big role in subsequent cognitive function.

Advertisement


In a paper published online in Nature Scientific Reports, researchers led by Tufts University/The Jackson Laboratory (JAX) Leah Graham and JAX Assistant Professor Gareth Howell, took a closer look at connections between diet and Alzheimer's disease susceptibility.

They used a "western diet" chow for mice developed by HHMI Professor Simon John, and members of his lab, that combines high amounts of animal products, fat and sugars with low plant-based content and nutrient density.
Advertisement

Previous studies had focused on specific components of the western diet, but it may be that the combination is important. Graham et al fed the chow to healthy mice of a commonly used inbred strain (C57BL/6J) and to mice that model some aspects of Alzheimer's disease (APP/PS1) for eight months (from two to 10 months of age, about the equivalent of late adolescence to early middle age in humans).

What the researchers found was that prolonged consumption of the western diet chow led to a dramatic increase in immune response activity in the brains of all mice, including those that don't model Alzheimer's disease.

The diet greatly increased the activity of microglia, which function as the brain's immune cells, and monocytes, circulating white blood cells that may cross into the brain in response to immune signaling.

Some components of the western diet have been associated with the development of peripheral inflammation over time, and the study's findings strengthen the possibility that immune activity in the brain increases Alzheimer's disease susceptibility.

All mice also had a significant increase of microglia/monocytes that express TREM2, a key immune regulatory protein. TREM2 has been strongly linked with susceptibility to Alzheimer's disease and other age-related neurodegenerative diseases, but this is the first study to show an increase in TREM2+ cells in response to prolonged consumption of a western diet.

Further, there was a strong correlation between increased TREM2+ cell numbers and increased beta-amyloid plaque burden in the brains of the mice, indicating that targeting TREM2 may be beneficial for patients with diet-induced cognitive decline.

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diet Pills Low Carbohydrate Diet Atkins Diet The Cabbage Diet South Beach Diet Parkinsons Disease Negative Calorie Diet Parkinsons Disease Surgical Treatment Bulimia Nervosa Why Do We Eat - Nutrition Facts 

Most Popular on Medindia

Blood Pressure Calculator Blood Donation - Recipients Iron Intake Calculator Pregnancy Confirmation Calculator Blood - Sugar Chart Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects Find a Hospital Hearing Loss Calculator Selfie Addiction Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

How Western Diet Triggers Amyloid Beta Plaque Formation in the Brain Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests