About My Health Careers Internship MedBlogs Contact us

How to Improve the Efficacy of Antipsychotics?

by Bidita Debnath on December 10, 2013 at 12:00 AM
Font : A-A+

 How to Improve the Efficacy of Antipsychotics?

At the Institut universitaire en santé mentale de Montréal and Université de Montréal, Philippe Vincent and Édouard Kouassi reported that the clinical context of the administration and dosage of antipsychotics may influence their efficacy.

The efficacy of most antipsychotics depends on their pharmacokinetics, or their ability to get into the bloodstream after being absorbed.


Vincent and Kouassi are responding in The Lancet to Stefan Leucht, who conducted a meta-analysis of over 200 articles on the efficacy and side effects of 15 antipsychotics.2 According to the data Leucht collected, five of the most recent second-generation antipsychotics (ziprasidone, aripiprazole, asenapine, iloperidone and lurasidone) were among the drugs with the lowest efficacy, despite having similar pharmacological properties compared to first-generation or to other second-generation antipsychotics. Leucht published his finding in The Lancet in September 2013; his article did not give any explanations for this surprising result.

Some antipsychotics require strict adherence on the part of patients. According to Vincent and Kouassi, specific conditions are required for some medications to be effectively absorbed. "For example, ziprasidone needs to be taken twice a day with a meal of 500 calories, whereas asenapine must absolutely melt under the tongue, and the patient must abstain from swallowing it, drinking, eating or smoking for 10 minutes afterward," Vincent said "This is a major challenge since more than one half of people with psychotic disorders do not take their medication as prescribed."

Vincent and Kouassi also state that the titration of these antipsychotics is a challenge in clinical practice, as it is difficult to obtain the optimal therapeutic dosage on the first try. Doctors therefore have to use an empirical approach. "The major side effects show up well before the optimum therapeutic dose is determined, which can discourage patients from continuing their treatment," Kouassi said. "Doctors have to keep trying, as the pharmacokinetics of antipsychotic compounds differ for each patient. By adjusting the dose of a medication based on the degree of blood absorption, distribution, metabolism and elimination in a patient, doctors can personalize treatment, which becomes that much more effective. We maintain that all antipsychotics, with the exception of clozapine, can achieve the same efficacy if they reach comparable blood levels."

If the studies reported by Leucht had compared medications in terms of their blood concentrations, we would have more accurate conclusions about the efficacy of the medication. "This confirms that the future of psychiatric medicine will involve personalizing patient care," Vincent said.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

Recommended Reading
District Nursing Homes Score High Marks for Quality While Antipsychotic Prescribing Remains Problematic
A study by the George Washington University School of Public Health and Health Services (SPHHS) was ...
Elderly Dementia Patients can Successfully be Taken Off Harmful Antipsychotic Drugs
Antipsychotic medication, used on older people to control behavioral and psychological symptoms of ....
Antipsychotic Administration is Associated With Stroke Risk in Elderly Patients
In elderly patients, antipsychotic administration is associated with an increased risk for ......
Pros and Cons of Antipsychotic Medications in Treating Depression
Antipsychotic medications are associated with small-to-moderate improvements in depressive symptoms ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use