About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

How Cells Limit Inflammation in Lung Injury Decoded by UIC Researchers

by Kathy Jones on December 20, 2011 at 8:44 PM
Font : A-A+

 How Cells Limit Inflammation in Lung Injury Decoded by UIC Researchers

A molecular mechanism that allows cells of the immune system to reduce tissue damage from inflammation has been discovered in an animal model of acute lung injury by researchers at the University of Illinois at Chicago College of Medicine.

The study is reported in Nature.

Advertisement

Inflammation is part of the normal response to infection. One aspect of inflammation is the production of negatively charged oxygen-rich molecules by specialized white blood cells called phagocytes. The molecules, called reactive oxygen species (ROS), help to break up bacteria, allowing the phagocytes to "mop up" the broken pieces and clear out the infection. Unfortunately, ROS can also cause damage to normal tissue.

The UIC researchers found that a channel through the cell membrane of phagocytes is able to modulate this destructive phase of inflammation.

"Although the channel, called TRPM2, is found in many cell types in the immune system, including phagocytes, it's function in these cells has been unknown," said Anke Di, UIC research assistant professor in pharmacology and first author of the study.
Advertisement

The researchers were able to show that TRPM2 had a protective anti-inflammatory role in the animal model of ALI, and, further, it played a previously unknown role in protecting against inflammation and tissue injury generally.

TRPM2's protective effect was a result of its ability to dampen the production of the negatively charged ROS by modulating the electrochemical gradient -- the difference in charge between molecules within the cell and outside the plasma membrane of the cell.

ALI and its more severe form, acute respiratory distress syndrome (ARDS) result from pulmonary edema (leaky blood vessels) and inflammation. Both direct lung injury from infection and indirect lung injury from trauma, sepsis, pancreatitis, transfusions, radiation exposure and drug overdose can trigger ALI. It is fatal in almost 40 percent of cases.

Inflammation plays an important role in ALI and a number of other human diseases, said Dr. Asrar Malik, UIC Schweppe Family Distinguished Professor and head of pharmacology and principal investigator of the study. Understanding how inflammatory damage to tissues is controlled normally may help develop therapies in the future, he said.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Athletes Foot Parkinsons Disease Surgical Treatment Pneumoconiosis Silicosis Anti-Inflammatory Diet Inflammation Top Ten Foods That Trigger Inflammation 

Recommended Reading
Congenital Cystic Adenomatoid Malformation Of The Lung
Congenital disease of the lung in which multiple cysts (water bubbles) develop in the lung tissues, ...
Lung Cancer Screening
Lung cancer accounts for nearly 1.3 million deaths annually worldwide. Lung cancer screening can ......
Anti-Inflammatory Diet
Healthy foods as part of anti-inflammatory diet to fight inflammation are basic components of the Me...
Athletes Foot
Athlete’s foot (tinea pedis/ringworm of the foot) is a fungal infection of the feet....
Inflammation
Inflammation is the response of living tissue to injury due to a variety of causes that call upon ho...
Pneumoconiosis
Pneumoconiosis is a group of lung diseases caused by inhaled dust particles. It causes inflammation ...
Silicosis
Silicosis is a lung disease caused by inhalation of crystalline free silica dust. It is characterise...
Top Ten Foods That Trigger Inflammation
Foods like refined carbohydrates, sugar, certain types of fat, artificial food additives and alcohol...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)