Cerebral ischemia injure neurons, and also involves the glial cells that provide a supportive scaffold to which the neurons are attached and the microvessels that provide energy for nervous tissue.
Therefore, protection of a single neuron is not sufficient to recover nervous function, and more attention should be paid to maintenance of the function of entire neurovascular units.
Houshiheisan compound is one of effective traditional Chinese compound prescriptions for stroke. The prescription is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs.
Hematoxylin-eosin staining revealed that after intragastric administration of Houshiheisan, the number of nerve cells was visibly increased and there was infiltration of a small number of inflammatory cells in the ischemic penumbra of rats with cerebral ischemia.