Cerebral ischemia injure neurons, and also involves the glial cells that provide a supportive scaffold to which the neurons are attached and the microvessels that provide energy for nervous tissue.
Therefore, protection of a single neuron is not sufficient to recover nervous function, and more attention should be paid to maintenance of the function of entire neurovascular units.
Treating Cerebral Ischemia
For treating cerebral ischemia/reperfusion, mesenchymal stem cell transplantation is a novel means and can promote angiogenesis and neurological functional recovery.
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Houshiheisan compound is one of effective traditional Chinese compound prescriptions for stroke. The prescription is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs.
Haizheng Wang and his team, School of Traditional Chinese Medicine, Capital Medical University in China, performed a study on Houshiheisan and found that the wind-dispelling and deficiency-nourishing drugs in the compound prescription Houshiheisan are complementary to each other, effectively suppress abnormal amyloid precursor protein accumulation, reduce amyloid substance deposition, maintain stabilization of the internal environment of neurovascular units, and minimize injury to neurovascular units in the ischemic penumbra by downregulating the amyloid-βexpression. Their findings were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).
![Treatment of Vascular Depression With Kaixin Jieyu Fang]( "Treatment of Vascular Depression With Kaixin Jieyu Fang")
The use of Kaixin Jieyu to treat vascular depression is known to be useful, but the underlying mechanism remains unclear.
Hematoxylin-eosin staining revealed that after intragastric administration of Houshiheisan, the number of nerve cells was visibly increased and there was infiltration of a small number of inflammatory cells in the ischemic penumbra of rats with cerebral ischemia.
Source: Eurekalert
Treatment of Vascular Depression With Kaixin Jieyu Fang
The use of Kaixin Jieyu to treat vascular depression is known to be useful, but the underlying mechanism remains unclear.
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Hematoxylin-eosin staining revealed that after intragastric administration of Houshiheisan, the number of nerve cells was visibly increased and there was infiltration of a small number of inflammatory cells in the ischemic penumbra of rats with cerebral ischemia.
Source: Eurekalert
Research Explores Use of Salvianolate for Treatment of Cerebral Ischemia-Reperfusion Injuries
Previous research has shown that salvianolic acid B is a phenolic acid compound composed of three Danshensu units and one molecule of caffeic acid.
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 Tau Protein Phosphorylation in Rats Subjected to Cerebral Ischemia-reperfusion InjuryHyperphosphorylation of the microtu-bule-associated protein tau induced by transient brain ischemia, shows a study. | Advertisement
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