About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Higher Radiation Therapy Does Not Improve Prognosis of Prostate Cancer

by Reshma Anand on March 29, 2016 at 12:23 PM
Font : A-A+

Higher Radiation Therapy Does Not Improve Prognosis of Prostate Cancer

Administration of higher doses of radiation to prostate cancer patients with fewer side effects, may not actually help a patient in the long term, at least not patients with localized prostate cancer. The results were published online in the American Journal of Clinical Oncology.

"In the field of radiation oncology, we often assume that the highest dose that the body can tolerate will be most effective at killing cancer," says Dr. Robert Den, M.D., a researcher at the Sidney Kimmel Cancer Center at Thomas Jefferson University and senior author on the paper. "Our results argue that this may not be the case, at least not with lower-risk prostate cancer patients."

Advertisement


Dr. Den, an Associate Professor of Radiation Oncology, Cancer Biology, and Urology at Jefferson, and colleagues analyzed data from 12 randomized controlled trials of external beam radiation treatment for men with non-metastatic prostate cancer, which included a total of 6884 patients. By pooling data from multiple clinical trials, the researchers were able to see trends that would not have been apparent in the individual studies.

Rather than use the typical proxy for patient improvement, the prostate cancer antigen (PSA) test, the researchers looked at long term outcomes such as the development of metastatic cancer and death from cancer. They found that while PSA levels decreased as patients received higher doses of radiation, the overall survival and incidence of metastases, among other measures, did not improve.
Advertisement

"It's important to check our assumptions," says Adam Dicker, Chair of Radiation Oncology at the Sidney Kimmel Medical College of Thomas Jefferson University. "This study suggests that our reliance on the PSA test as a proxy for patient outcomes may not as useful as many researchers thought, which has broad implications for the design of future clinical trials and the interpretation of current and previous studies."

Dr. Den's study also demonstrated that increasing dose was not associated with worse treatment toxicity, suggesting that current practices are safe. "These data suggest that other therapies may be needed with radiation to increase survival," says Dr. Den.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Radiotherapy Prostate Cancer X-Ray Cancer and Homeopathy Trans-Urethral Resection of the Prostate Hodgkins Lymphoma Non-Hodgkins Lymphoma Reiki and Pranic Healing Prostate Cancer Facts Cancer Facts 

Most Popular on Medindia

Sanatogen Diaphragmatic Hernia Iron Intake Calculator Selfie Addiction Calculator Indian Medical Journals How to Reduce School Bag Weight - Simple Tips Hearing Loss Calculator Find a Doctor A-Z Drug Brands in India Loram (2 mg) (Lorazepam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Higher Radiation Therapy Does Not Improve Prognosis of Prostate Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests