Aspirin is used extensively as a blood thinner to lower risk of heart
Interestingly a new study suggests that aspirin
positive side effect- that of lowering risk of dying due to prostate cancer. In
other words, prostate cancer progression to lethal state is lowered.
There was a 40% reduction in risk of death due to prostate cancer among
patients who took aspirin,
according to urologic Oncology Fellow and principal researcher Dr
Christopher Allard. The results of the study were presented on January 4th
2016 at the American Society Of Clinical Oncology in San Francisco.
‘Aspirin is used extensively as a blood thinner to lower risk of heart attack. New studies indicate that regular use of aspirin has additional benefit in prostate cancer patients, as it lowers the risk of developing lethal cancers in such patients. ’
This observational study based its
research findings by studying real life users of aspirin who also had prostate
cancer. This study found that prostate cancer
patients who use aspirin for
cardiovascular benefits will now have added reasons to use it regularly.
About the study:
The study began in 1982 to study
the effect of aspirin and beta carotene on cancer.
- 22,000 men were included in the
- 3,400 developed prostate cancer
developed lethal prostate cancer
Only a relatively small proportion
of patients developed lethal prostate cancer. Lethal prostate cancer is death
due to prostate cancer or spread of prostate cancer to other organs.
Further, it was found that
- Men who were not diagnosed with
prostate cancer but who took aspirin at least thrice a week had a 24% lower
risk of developing lethal prostate cancer
- Men who were
diagnosed with prostate cancer and who regularly took aspirin had a 39% lower
risk of developing lethal prostate cancer.
This study was an observational
study and not a controlled trial. Therefore additional studies would have to be
performed to corroborate the results of this study.
Dr Sumanta Pal, spokesperson for
ASCO and an Oncologist found this study 'intriguing' but added a note of caution
that patients should seek expert medical help before taking aspirin.
Other top research publication on
aspirin and prostate cancer in 2015 that add substance to above conclusion includes -
1. " Preventing aggressive prostate cancer with
proven cardiovascular disease preventive methods"
published by Mark A. Moyad from
the Department of Urology, University of Michigan. This study found that
cardiovascular disease risk factors like obesity
glucose intolerance, unhealthy dietary habits
were also risk factors for prostate
cancer. Lowering the cardiovascular preventive risk factors and the use of
, aspirin and metformin
have been found to be effective in
lowering prostate cancer risk.
2. " Impact of aspirin on clinical outcomes for
African American men with prostate cancer undergoing radiation"
by Osborn VW, Chen SC, Weiner J,
Schwartz D and Schreiber D. This study found that the use of aspirin improved
biochemical outcomes as well as metastasis of African men with prostate cancer.
sensitivity to aspirin is associated with altered polyamine metabolism in human
prostate cancer cells"
by Li J,
Aspirin was found to inhibit the growth of cancer cells. Aspirin induced
spermine N acetyltransferase in human cancer cells and these cells grew more
slowly when compared with cancer cells that were not induced.