The brain has Gephyrin, a central scaffolding protein for inhibitory neurotransmitter receptors. A neurotransmitter receptor is a membrane receptor protein, activated by a neurotransmitter.
A membrane protein interacts with the phospholipid bilayer that encloses the cell and a membrane receptor protein interacts with a chemical in the cells external environment, which binds to the cell.
Membrane receptor proteins, in neuronal and glial cells, allow cells to communicate with one another through chemical signals.
The development of dimeric peptides inhibits the interaction between gephyrin and these receptors.
It is a process, which is fundamental to numerous synaptic functions and diseases of the brain.
Receptor-derived minimal gephyrin-binding peptides were identified. It displayed exclusive binding towards native gephyrin from brain lysates.
The crystal structures were visualized in X-ray and the simultaneous dimer-to-dimer binding in atomic detail, revealing compound-specific binding modes.