Formoterol is Effective and Safe in Patients With COPD

by Dr. Simi Paknikar on  December 2, 2011 at 2:32 PM Health In Focus
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Formoterol is an effective and safe drug in the treatment of COPD, according to a recent study.
 Formoterol is Effective and Safe in Patients With COPD
Formoterol is Effective and Safe in Patients With COPD

Chronic Obstructive Pulmonary Disease (COPD) is a lung condition wherein the patient suffers from symptoms of breathlessness, cough and reduced exercise capacity. Drugs that dilate the bronchi (the branches of the airways) are used to relieve the obstruction and help the patient to breathe. These drugs may be short-acting like salbutamol, or long-acting like salmeterol and formoterol.

The effects of formoterol and placebo in COPD patients were compared in a study recently published in BMC Pulmonary Medicine. The aim of the study was to establish the usefulness of the long-acting drug in COPD as well as to test its safety in COPD patients. Some prior studies had suggested that long-acting bronchodilators could increase the risk of death in these patients.

The study was carried out on a total of 613 patients of European and Japanese origin. Some patients received 4.5g of formoterol twice daily, others received a doubled dose of 9g of formoterol twice daily, and still others received a placebo (an inert substance for comparison purpose). The patients were administered the drug for a total duration of 12 weeks. Lung function was measured using a spirometer. Patients who needed additional medication could take the short-acting drug salbutamol whenever required. They could also continue to take short-acting anticholinergics as earlier.

At the end of the study period, it was found that the measured lung function (which was FEV1 60-min post-dose in the study) improved significantly in both the formoterol groups as compared to placebo. There was no significant difference between the two formoterol groups.

The improvement in clinically-relevant quality of life, as measured by a questionnaire, was significantly higher with formoterol 9g as compared to placebo. However, there was no clinically-significant improvement in quality of life with 4.5g formoterol as compared to placebo. Both groups on formoterol required less additional salbutamol treatment as compared to placebo; the group on the higher dose also required less salbutamol rescue as compared to the lower dose.

Most side effects in patients with formoterol were similar in number as compared to placebo. Side effects included nasopharyngitis (inflammation of the nose and throat), COPD exacerbation, and bronchitis complication. Two deaths occurred in the formoterol groups, but they were unrelated to the treatment.

Thus, formoterol is an effective drug in improving COPD at doses of 4.5g as well as 9g twice a day, with the twice daily dose of 9g providing some additional benefits. Thus, the study refutes the conclusions of some earlier studies which state that formoterol treatment can cause more deaths in COPD patients.

References :

1. Bogdan MA, Aizawa H, Fukuchi Y, Mishima M, Nishimura M, Ichinose M. Efficacy and safety of inhaled formoterol 4.5 and 9 μg twice daily in Japanese and European COPD patients: Phase III study results. BMC Pulmonary Medicine 2011, 11:51 doi:10.1186/1471-2466-11-51

Source: Medindia

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