The health of the mother during pregnancy and the intrauterine environment can have dramatic and lasting effects on the child.

They found that as teenagers, individuals born to women with ICP had altered metabolic profiles and increased BMI. To further understand this effect, Williams and colleagues developed a mouse model of ICP and found that offspring of ICP mothers were more susceptible to metabolic disease and diet-induced obesity.
In the companion commentary, Susan Murphy of Duke University points out that the mouse model of ICP may also be useful in identifying other factors that predispose individuals to metabolic syndrome.
Source-Eurekalert
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