Mitochondrial Regulator ATAD3A & Head and Neck Cancer
Targeting these oncoproteins could offer a novel approach to developing effective cancer therapeutics. However, non-specific targeting of mitochondrial functions has significant unwarranted effects on normal cell growth, and it could lead to unwanted side effects.
Head and Neck Cancers - Types, Risk Factors, Symptoms, Diagnosis, Treatments
Head and neck cancers usually occur in the squamous cells lining the moist, mucosal surfaces inside the head and neck.
Head and neck cancers usually occur in the squamous cells lining the moist, mucosal surfaces inside the head and neck.
‘Continued research on ATAD3A, the molecular determinant provides key insights into the molecular mechanisms underlying head and neck cancer progression. ’
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In this new research perspective, researcher Yong Teng from Emory University and Georgia Institute of Technology discusses the importance of developing refined strategies that can specifically target oncoproteins that are physically localized to mitochondria in cancer cells. The mitochondrial ATPase family AAA domain containing protein 3 (ATAD3) belongs to the AAA+ superfamily of ATPases and is involved in various cellular processes. In a previous study, it was demonstrated that ATAD3A overexpression in breast cancer cells promoted metastasis to the lung and liver in a mouse model, while its knockdown suppressed metastasis.
Source-Eurekalert
Quiz on Head and Neck Cancer
Head and neck cancers begin in squamous cells that line the moist, mucosal surfaces inside the head and neck. These kinds of cancers related to squamous cells are referred to as squamous cell carcinomas.
Cancers of head and neck are further differentiated by the area of head and neck in which they begin. This form of cancer starts in lip, oral cavity (mouth), nasal cavity, paranasal sinuses, pharynx and larynx.
Cancers in brain, eye, esophagus, thyroid gland, scalp, muscles and bones of head and neck are not categorized under head and neck cancers. In some cases, squamous cells can be found in lymph nodes of upper neck when there is no evidence of cancer in other parts of head and neck. If this happens, cancer is called metastatic squamous neck cancer with unknown (occult) primary.
Head and neck cancers begin in squamous cells that line the moist, mucosal surfaces inside the head and neck. These kinds of cancers related to squamous cells are referred to as squamous cell carcinomas.
Cancers of head and neck are further differentiated by the area of head and neck in which they begin. This form of cancer starts in lip, oral cavity (mouth), nasal cavity, paranasal sinuses, pharynx and larynx.
Cancers in brain, eye, esophagus, thyroid gland, scalp, muscles and bones of head and neck are not categorized under head and neck cancers. In some cases, squamous cells can be found in lymph nodes of upper neck when there is no evidence of cancer in other parts of head and neck. If this happens, cancer is called metastatic squamous neck cancer with unknown (occult) primary.
Handling Body Image Distress in Head and Neck Cancer
Brief tele-cognitive behavioral therapy for head and neck cancer survivors with body-image distress shows promising results.
Brief tele-cognitive behavioral therapy for head and neck cancer survivors with body-image distress shows promising results.
New Combo Treatment for Head and Neck Cancer Discovered
A potential new treatment for head and neck cancer (HNC), using a targeted drug and immunotherapy has been developed by researchers.
A potential new treatment for head and neck cancer (HNC), using a targeted drug and immunotherapy has been developed by researchers.
