Reactivation of genital herpes is linked in some cases with the emergence of widespread neuropathic pain, according to a Finnish study reported in The Journal of Pain.
In the clinic at the University of Helsinki, 17 patients were examined who presented widespread chronic pain with no visible lesions in brain magnetic imaging. Because the majority had herpes simplex virus (HSV) infections, the researchers studied a possible association between herpes and neuropathic pain. They hypothesized that in HSV-positive patients, the active virus may alter pain processing at different levels of the central nervous system (CNS).
Results of the study showed 80 percent of the patients reported at least moderate pain relief with anti-herpetic medication, and in more than half there was positive correlation between the activity of the HSV infection and pain.