About Careers MedBlog Contact us

Gene Variations may Increase the Risk of Chronic Pain Following an Amputation, Study

by Dr. Enozia Vakil on October 15, 2013 at 2:17 PM
Font : A-A+

 Gene Variations may Increase the Risk of Chronic Pain Following an Amputation, Study

Researchers have identified more than a hundred different variation in a patient's DNA sequence that could help predict chronic pain after amputation.

From 2000 to 2011, there were 6,144 amputations among 5,694 injured service members, according to the Armed Forces Health Surveillance Center. More than one-third had major amputations, defined as the loss of a hand, foot or more.


"Traumatic amputations of limbs profoundly change the lives of affected military service members," said Andrew D. Shaw, M.D., associate professor of anesthesiology and critical care medicine, Duke University Medical Center, Durham, N.C. "Persistent pain after amputation is a serious problem with no effective treatments. By identifying these 'pain genes', we may be able to discover the reasons why pain occurs and predict which patients are more likely to have it. In the future, we hope to discover the biology of persistent pain and develop ways to combat it."

In the study, blood was collected for DNA, RNA and plasma extraction from 49 service members who had amputations and persistent pain. These blood samples were then mapped using Exome Sequencing technology to identify any variations the military service members have in common.

Hundreds of new DNA sequence variations previously unknown were identified as pathways of biological importance as the possible source of chronic, persistent pain for service members, according to the study.

"This is one of the first studies where 'pain genes' have been identified in humans using next-generation sequencing," explained Dr. Shaw. "We have known about some of them in lab studies. Now that we have identified these gene variations, we need to study them and then create new medicines to prevent and relieve the chronic pain for these patients."

The American Society of Anesthesiologists
Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 50,000 members organized to raise and maintain the standards of the medical practice of anesthesiology. ASA is committed to ensuring physician anesthesiologists evaluate and supervise the medical care of patients before, during and after surgery to provide the highest quality and safest care every patient deserves.

Source: Newswise


Recommended Reading

Latest Lifestyle and Wellness News

Defying Time: Unlocking the Secrets to Wrinkle-Free Skin
Decoding the secrets of wrinkles by knowing the causes, prevention, and expert advice.
Summer's Gaze: Prioritizing Eye Care!
With the arrival of summer and the lure of outdoor activities, it is essential to give equal importance to the well-being of your eyes and skin.
Summer Makeup Battle: Conquering Humidity and Heat
Combination of high humidity and scorching heat in summer poses a daunting task for makeup wearers; balancing it is thus crucial.
Protecting Yourself from Summer Sun: Tips and Tricks
Selecting the right SPF for your skin is quite tricky, but the thumb rule is to use sunscreen with an SPF of at least 30 for effective results.
 World Family Doctor Day: Let's Celebrate the Family Doctors at the Heart of Healthcare
World Family Doctor Day held on 19th May highlights the vital role and contribution of family doctors in healthcare systems worldwide.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Gene Variations may Increase the Risk of Chronic Pain Following an Amputation, Study Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests