Gene Variants Linked to an Increased Risk of Childhood Cancer

by Kanimozhi Tamilselvan on  September 26, 2017 at 9:47 AM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

Gene variants that are linked to childhood cancer neuroblastoma have been identified. This discovery may assist doctors in better understanding and diagnosing the subtypes of neuroblastoma.
Gene Variants Linked to an Increased Risk of Childhood Cancer
Gene Variants Linked to an Increased Risk of Childhood Cancer

Co-led by a genomics expert and a pediatric oncologist with expertise in neuroblastoma, a team from Children's Hospital of Philadelphia (CHOP) reported that common variants in the MMP20 gene are associated with deletions on chromosome 11q. "These inherited variants predispose to 11q deletions, which are a strong risk factor for an aggressive form of neuroblastoma," said co-study leader Hakon Hakonarson, MD, PhD, director of the Center for Applied Genomics at CHOP.

Show Full Article


The study appeared in Nature Communications.

"We already knew that 11q deletions are biomarkers that predict poor outcomes in neuroblastoma," said co-study leader John M. Maris, MD, a pediatric oncologist at CHOP's Center for Childhood Cancer Research. "This new research helps us to more precisely predict how a neuroblastoma tumor will behave, so it improves our diagnostic capabilities."

A cancer of the peripheral nervous system that usually occurs as a solid tumor in a child's chest or abdomen, neuroblastoma is the most common cancer in infants. It accounts for a disproportionate share of cancer deaths in children.

The CHOP researchers previously identified six other genetic risk variants for neuroblastoma over the past decade, so the current investigation offers new insights into the genetic architecture of this complex form of cancer.

In the current study, the team performed a genome-wide association study in 113 tumors from neuroblastoma patients harboring 11q deletions, compared to 5,100 ancestry-matched controls. The research yielded common variants in the MMP20 gene, located on chromosome 11q22.2. A replication study in 44 independent cases and 1,900 controls found similar results.

The authors added that further studies should investigate the mechanisms by which MMP20variants give rise to neuroblastoma tumors.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive