About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Gene Variant may Help Decode the Psychotic Behaviour in Bipolar Disorder Patients

by Dr. Enozia Vakil on March 8, 2013 at 5:17 PM
Font : A-A+

 Gene Variant may Help Decode the Psychotic Behaviour in Bipolar Disorder Patients

Researchers at the Karolinska Institute explain the elevated levels of kynureic acid in the brains of schizophrenia and bipolar disease patients. The study, which is published in the scientific periodical Molecular Psychiatry, identifies a gene variant associated with an increased production of KYNA. The discovery contributes to the further understanding of the link between inflammation and psychosis - and might pave the way for improved therapies.

Kynurenic acid (KYNA) is a substance that affects several signalling pathways in the brain and that is integral to cognitive function. Earlier studies of cerebrospinal fluid have shown that levels of KYNA are elevated in the brains of patients with schizophrenia or bipolar diseases with psychotic features. The reason for this has, however, not been fully understood.

Advertisement

KMO is an enzyme involved in the production of KYNA, and the Karolinska Institute team has now shown that some individuals have a particular genetic variant of KMO that affects its quantity, resulting in higher levels of KYNA. The study also shows that patients with bipolar disease who carry this gene variant had almost twice the chance of developing psychotic episodes.

KYNA is produced in inflammation, such as when the body is exposed to stress and infection. It is also known that stress and infection may trigger psychotic episodes. The present study provides a likely description of this process, which is more likely to occur in those individuals with the gene variant related to higher production of KYNA. The researchers also believe that the discovery can help explain certain features of schizophrenia or development of other psychotic conditions.
Advertisement

"Psychosis related to bipolar disease has a very high degree of heredity, up to 80 per cent, but we don't know which genes and which mechanisms are involved," says Martin Schalling, Professor of medical genetics at Karolinska Institutet's Department of Molecular Medicine and Surgery, also affiliated to the Center for Molecular Medicine (CMM). "This is where our study comes in, with a new explanation that can be linked to signal systems activated by inflammation. This has consequences for diagnostics, and paves the way for new therapies, since there is a large arsenal of already approved drugs that modulate inflammation."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Quiz on Depression Bipolar Disorder Weaver Syndrome Loss of Taste Schizoaffective Disorder Euphoria Social Anxiety Disorder Anosognosia Mood Swings 

Recommended Reading
Bipolar Disorder
Bipolar Disorder is a brain disorder in which people show "mood swings". Changes in the level of .....
The Biological Matrix of Bipolar Disorder: An Effort In Understanding It
The brain becomes increasingly complex as we begin to understand it even further....
Anosognosia
Anosognosia is the lack of awareness or insight in a patient to understand that he/she has a disease...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Euphoria
Euphoria is an exaggerated state of happiness and well-being that is beyond the normal emotional res...
Loss of Taste
Symptom of loss of taste usually occurs in combination with loss of smell and can be complete loss o...
Mood Swings
It is normal to go through mood changes such as joy, sadness or anger every day, but when these mood...
Schizoaffective Disorder
Schizoaffective disorder is a serious mental disorder in which the individual reflects symptoms that...
Social Anxiety Disorder
Social anxiety disorder is a common mental health problem where a person is abnormally fearful of so...
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use