New study had demonstrated the effectiveness of direct delivery of gene therapy into the brain of a mouse model of chronic traumatic encephalopathy.
Gene Therapy for Macular Degeneration
Gene therapy gives new hope for age-related blindness. Scientists were able to deliver the gene for a retinal opsin into the genome of ganglion cells using an adeno-associated viral vector. The blind ganglion cells were restored and became sensitive to light.
Gene therapy gives new hope for age-related blindness. Scientists were able to deliver the gene for a retinal opsin into the genome of ganglion cells using an adeno-associated viral vector. The blind ganglion cells were restored and became sensitive to light.
‘There is currently no treatment for chronic traumatic encephalopathy, which is caused by repeated trauma to the central nervous system (CNS), such as that suffered by soldiers, athletes in contact sports, and in accident-related trauma. ’
Ronald Crystal and colleagues from Weill Cornell Medical College, New York, NY, coauthored the article entitled "Anti-Phospho-Tau Gene Therapy for Chronic Traumatic Encephalopathy."
Inflammation results in the accumulation of hyperphosphorylated forms of Tau protein (pTau). Crystal et al. developed an adeno-associated virus (AAV) vector to deliver an anti-pTau antibody to the (CNS). They showed that direct delivery of the AAVrh.10anti-pTau directly into the hippocampus of brain-injured mice was associated with a significant reduction in pTau levels across the CNS. They propose that doses could be scaled up and this strategy could be effective in humans as well.
"CTE is much more prevalent than was initially realized, and there is currently no therapy available," says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, Worcester, MA. "This new work from the Crystal laboratory is potentially ground-breaking as a means to remove the offending Tau phoshoprotein."
Chronic Traumatic Encephalopathy - Causes, Symptoms, Diagnosis, Treatment, Prevention
Chronic traumatic encephalopathy is a concussion related brain disease in people suffering from repeated traumatic brain injuries.
Chronic traumatic encephalopathy is a concussion related brain disease in people suffering from repeated traumatic brain injuries.
Brain Depression
Interactive section of Medindia provides information about chemistry of Brain depression
Interactive section of Medindia provides information about chemistry of Brain depression
Encephalopathy Severity Ups With Years Playing American Football
The risk and severity of developing chronic traumatic encephalopathy (CTE) increase with the number of years playing American football, stated new study.
The risk and severity of developing chronic traumatic encephalopathy (CTE) increase with the number of years playing American football, stated new study.
