About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Find Out Why Brain is More Sensitive to Oxygen Deprivation

by Bidita Debnath on October 31, 2017 at 11:54 PM
Font : A-A+

Find Out Why Brain is More Sensitive to Oxygen Deprivation

The brain depends on oxygen to perform even the most basic functions. Without it, the brain quickly ceases to function. And if oxygen deprivation continues, death or permanent brain damage takes just a few minutes.

Hypoxia caused by a stroke, for example, activates a specific mechanism that is protective in other organs but can be detrimental to the brain. Researchers at Maastricht University Medical Center and Maastricht University have discovered why the brain is more sensitive to oxygen deprivation, or hypoxia, than other organs.

Advertisement


'This discovery solves a long-standing mystery of the unique sensitivity of the brain to hypoxia,' says head researcher and professor Harald Schmidt. The research results were published today in the leading scientific journal Proceedings of the National Academy of Sciences U.S.A. (PNAS).

In most cases, a stroke is caused by a blocked artery in the brain, which deprives the brain of oxygen. To prevent brain death, the blood clot must be dissolved with an anticoagulant or removed via a catheter. Stroke victims that survive are left with detrimental symptoms, regardless of how quickly they were treated. These symptoms may include severe paralysis and speech disorders.
Advertisement

Self-destruction

An enzyme was found to play a crucial and specific role during a stroke. Following oxygen deprivation, this enzyme, known as NOX4, is produced by several organs and muscles. In all investigated cases, however, NOX4 is harmless, with one notable exception: the production of NOX4 in the brain is disastrous. How this happens is now clear down to the cellular level. First, the enzyme triggers the breakdown of cells of the blood-brain barrier, which protects the brain against blood and other components. Second, NOX4 also triggers a self-destruction mechanism in neurons. This combined effect results in physical and mental problems. When the NOX4 gene is deleted or the NOX4 enzyme inhibited with drugs, the blood-brain barrier and neurons remain intact and brain damage is prevented.

Therapy

This important finding opens news doors for treating post-stroke brain damage. "We've known for some time that oxygen deprivation leads to brain damage, we just never knew why. The crucial role the NOX4 enzyme plays will help us develop new treatment options to protect the brain after a stroke.' With the help of a proof-of-concept grant provided by the European Research Council the Maastricht researchers are already one step further by developing drugs that are capable of inhibiting the disastrous effects of this enzyme as soon as possible for patient therapy.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Brain Facts Ataxia Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) Hypoxia 

Recommended Reading
How Does the Brain Remember All That We Memorize?
The brain has the capacity to retain information and also does not overlap the new facts with the .....
Brain Imaging Can Help Indicate Readiness of Trainees To Operate
Before surgeons enter an actual operating room, they are exposed to a set up that is similar to the ...
Alzheimer's Patients Working Memory could be Associated with Brain's Adaptability
Brain's plasticity has been found to be significantly lower in Alzheimer's patients; this discovery ...
Brain Tumors Usually Share Common Tricks to Survive
Different types of brain tumours may use strikingly similar approaches to generate and use energy .....
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Hypoxia
Hypoxia is the term used to denote a deficiency in the amount of oxygen reaching the tissues....
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use