The present study, lead by Dr. Hattori and her colleagues from Kanazawa University Graduate School of Medical Science, has recently been published on July 7, 2009 in the
. The study investigated the relationship between enhancement on dynamic CT and vascular endothelial growth factor and microvessel density as indicators of angiogenesis, and the extent of fibrosis.
Tumors with strong angiogenesis tended to show high enhancement in the arterial dominant phase. On the other hand, tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. There was a significant correlation between enhancement on conventional dynamic CT and angiogenesis in pancreatic cancer. However, dynamic CT features that are caused by angiogenesis may be modified by the extent of intratumoral fibrosis.
For the present, anti-angiogenesis agents are still not approved for the treatment of pancreatic cancer. However, as a preliminary investigation for future clinical application, prediction of the grade of angiogenesis by conventional dynamic multidetector CT, which is most often performed for the diagnosis of pancreatic cancer, would be useful clinically.