The new recommendations focus on products that contain opioid painkiller hydrocodone along with combination of the painkiller with over-the-counter painkiller like acetaminophen or aspirin.
With the changes coming into force, patients will have to carry prescriptions to pharmacies, instead of their doctors calling it in, and will also limit the number of refills patients could get before they have to see their doctor again.
Stating that the agency is concerned over rising misuse and abuse of painkillers, the director of FDA's Center for Drug Evaluation and Research, Dr Janet Woodcock said, "These are very difficult trade-offs that our society has to make. The reason we approve these drugs is for people in pain. But we can't ignore the epidemic on the other side."