Children of stressed fathers have a higher risk of developing a mental disorder.

‘Children of stressed fathers are at an increased risk of developing post traumatic stress disorder (PTSD) and depression.’

But the researchers, led by neuroscientist Tracy Bale at the University of Maryland School of Medicine, now show that a father's stress can also affect offspring development, by altering important aspects of his sperm.
Bale will discuss this new, not-yet-published work at a special session and press conference at the 2018 AAAS annual meeting in Austin, Texas on Friday, February 16. 




Previously, Bale had found that adult male mice experiencing chronic periods of mild stress have offspring with a reduced response to stress; changes in stress reactivity have been linked to some neuropsychiatric disorders, including depression and PTSD. She and her colleagues isolated the mechanism of the reduced response; they found that the father's sperm showed changes in genetic material known as microRNA. MicroRNA are important because they play a key role in which genes become functional proteins.
Now, Bale and her colleagues have unraveled new details about these microRNA changes. In the male reproductive tract, the caput epididymis, the structure where sperm matures, releases tiny vesicles packed with microRNA that can fuse with sperm to change its cargo delivered to the egg. The caput epididymis responded to the father's stress by altering the content of these vesicles.
This suggests that even mild environmental challenges can have a significant impact on the development and potentially the health of future offspring. By learning more about links between a father's exposure to stress and the risks of disease for his offspring, we can better understand, detect, and prevent these disorders.
Bale has focused much of her research on the links between stress and subsequent risk for neurodevelopmental disorders, including autism and schizophrenia, in offspring. Her previous studies on the placenta have revealed novel sex differences during pregnancy that may predict increased prenatal risk for neurodevelopmental disorders in males.
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