Fasting Combined With Less Toxic Drugs may Replace Chemotherapy

by Dr. Trupti Shirole on April 2, 2015 at 4:51 AM

Fasting Combined With Less Toxic Drugs may Replace Chemotherapy
Currently used cancer treatment options vary from surgery, chemotherapy, radiation, to many other therapies. Chemotherapy involves the use of drugs to destroy cancer cells, but can also harm perfectly healthy cells, causing side effects throughout the body. Fasting in combination with chemotherapy has already been shown to kill cancer cells more efficiently than chemotherapy alone. Researchers have now discovered that fasting combined with a less-toxic class of drugs, kinase inhibitors, may starve cancer cells to death so effectively that the new treatment may one day replace chemotherapy.

Cancer cells rely heavily on glucose (sugar) from food for energy. They are on overdrive, burning much more glucose than a regular cell to fuel their rapid growth. This phenomenon is called the 'Warburg effect', which is named after the German physician who first described it nearly 100 years ago. The study pointed out that deprived of glucose, cancer cells rely on an emergency backup, using a type of enzyme called kinase to continue their growth-related activities.

Researchers discovered that this metabolic shift by cancer cells causes them to generate toxic-free radicals, which ultimately kills them. The researchers noted that with the help of kinase inhibitor drugs, cancer cells' ability to generate energy can be further choked. Kinase inhibitors are already approved by the US Food and Drug Administration (FDA) as a cancer treatment option, opening the door to using them and fasting as a new therapy to knock out cancer.

Valter Longo, senior author from University of Southern California Davis School of Gerontology, said, "If shown to work in humans, this combination could replace chemotherapy and make fasting a potent component of a long-term strategy to treat cancer. Like every other cell, cancer cells need energy to survive and keep growing. But cancer cells are fairly inflexible about how they produce that energy, which gives us a way to target them. Kinase inhibitors, though much less toxic than chemotherapy, can still be toxic to many cell types. Fasting makes them more effective, meaning that patients would have to use them for less time to achieve the same results."

The study is published in Oncotarget.

Source: Medindia

News A-Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Peritoneal Cancer Hunger Fullness and Weight Control Drugs Banned in India Rhabdomyosarcoma 

Recommended Reading
Anti-cancer Treatment Could Become Cheaper
The Re Do project is striving to reduce the cost of anticancer treatment by using some drugs ......
Cancer Pain
Every 1 out of 3 people undergoing cancer treatment experiences pain....
New Approach Accelerates Identification of Cancer Treatments
At the University of Michigan, researchers have described a new approach to discovering potential .....
Necessity of Further Cancer Treatment may be Predicted by Gene
The requirement for follow-up treatment of patients with breast cancer and certain lung cancers can ...
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chemotherapy Drugs
Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body....
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Hunger Fullness and Weight Control
An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the m...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Peritoneal Cancer
Peritoneal cancer is a rare cancer that develops in the peritoneum. Peritoneal cancers may be primar...
Rhabdomyosarcoma is a rare type of cancer affecting the striated muscles. It mostly occurs in ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use