About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Effectiveness Of Ecopipam in Treating Stuttering

by Bidita Debnath on September 24, 2016 at 5:56 PM
Font : A-A+

 Effectiveness Of Ecopipam in Treating Stuttering

Stuttering, a genetically influenced condition, appears to originate when various aspects of a young child's development interact, and is best addressed with early intervention. No cure for it has been found, but behavioral treatment options are available. Currently, no Food and Drug Administration (FDA)-approved drug treatments are available.

In an attempt to find a new medicine, a research team at the School of Medicine at the University of California, Riverside, in partnership with the speech pathology laboratory at the University of Redlands, will conduct a study at CITrials in Riverside, Calif., to determine how effective ecopipam, an orally administered medication, is as treatment against stuttering.

Advertisement


Ten volunteers will be selected to participate in the FDA-approved clinical trial. The study, scheduled to begin next month, is seeking volunteers, although space is limited. People interested in participating in the study may contact Gerald Maguire, M.D., the chair of psychiatry and neuroscience at UC Riverside and the associate dean for graduate medical education, who is leading the study: gerald.maguire@medsch.ucr.edu.

"The study is exploratory," Maguire said. "We are the only site in the world conducting this trial; ecopipam has never been tested for stuttering. It has been tested for treatment of tics in Tourette syndrome, a neurological disease, with some encouraging results. Stuttering shares some similarities to the vocal changes seen in subjects with Tourette syndrome. We are hopeful ecopipam will yield beneficial effects in stuttering."
Advertisement

Ecopipam is a first-in-class drug that selectively blocks the actions of the neurotransmitter dopamine at its receptor. Dopamine receptors can be broadly classified into two families based on their structures: D1 receptors and D2 receptors. Ecopipam blocks dopamine only at D1 receptors, and thus acts differently than other commercially available medications. This mechanism explains why ecopipam is being tested as a potential treatment for stuttering.

The 10 patients selected for the clinical trial next month will undergo a physical examination and their medical history will be recorded. To ensure that their stuttering symptoms are sufficiently severe, their speech patterns will be analyzed by Professor Lisa LaSalle, a speech pathologist at the University of Redlands, and co-investigator on the study. Each patient will receive ecopipam for a limited time.

"We believe we could have results from our analysis in as soon as nine months," Maguire said. "A placebo-controlled clinical trial may then follow, pending approval. If ecopipam is found to be effective in controlling stuttering, we may have a viable solution for a disorder that can be traced back centuries."

The study is being funded through philanthropic donations given to UCR specifically to study stuttering. Psyadon, a pharmaceutical company focused on treatments for neurology and psychiatry, will donate ecopipam.

Earlier this year, Maguire was elected chair of the board of directors of the National Stuttering Association (NSA), a non-profit organization dedicated to bringing hope and empowerment to children and adults who stutter.

A professor of psychiatry and neuroscience and a stutterer himself, Maguire earned his medical degree from St. Louis University School of Medicine in 1991 and his residency in psychiatry in 1995 from UC Irvine. His research interests include the medical treatments of stuttering and the pharmacologic treatment of schizophrenia, bipolar disorder, major depressive disorder and Alzheimer's dementia.

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stuttering Stuttering - Coping and Relaxation 

Most Popular on Medindia

Hearing Loss Calculator Iron Intake Calculator Blood Pressure Calculator Find a Hospital Pregnancy Confirmation Calculator Drug Side Effects Calculator Calculate Ideal Weight for Infants Blood - Sugar Chart Selfie Addiction Calculator Turmeric Powder - Health Benefits, Uses & Side Effects
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Effectiveness Of Ecopipam in Treating Stuttering Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests