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Effective Use Nerve Transfer in Treating Patients With Brachial Plexus Injuries can Improve Quality of Life

by Kathy Jones on May 5, 2013 at 7:11 PM
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 Effective Use Nerve Transfer in Treating Patients With Brachial Plexus Injuries can Improve Quality of Life

The quality of life in patients who are suffering from brachial plexus injuries can be improved by the effective use of nerve transfer in reconstruction of elbow flexion, a new study presented at the 81st American Association of Neurological Surgeons (AANS) Annual Scientific Meeting reveals.


With the rise in recent years of nerve transfers as an option for brachial plexus injuries, the researchers reviewed the clinical outcomes of their patients who have undergone different nerve transfers for restoration of elbow flexion between January 2001 and December 2011. Researchers retrospectively analyzed the medical records, electrophysiological examinations and radiological images of 107 patients who underwent nerve transfer operations in the aforementioned timeframe. Pre- and post-operative assessment of motor function was carried out using the Medical Research Council (MRC) grading scale. The results of this study, 10-year experience with nerve transfers for restoration of elbow function in patients with traumatic brachial plexus injuries, will be presented by Julia Oberhoffer, MD, from 11:08-11:19 a.m. on Tuesday, April 30. Co-authors are Gregor Antoniadis, PhD; Ralph KÃnig, PhD; Christian Heinen, MD; Thomas Kretschmer, PhD; Christian Wirtz, PhD; and Maria Pedro, MD.

During the time period reviewed, a total of 107 patients with a brachial plexus injury were treated by nerve transfer surgery in the researchers'' institute, with seven patients lost to follow up. The average follow up was 23 months, and 49 percent of the patients recovered to MRC 3. The best results could be achieved by transferring the medial pectoral to musculocutaneous nerve (MCN), where 82 percent (n=11) recovered to MRC 3. Seventy-four percent of 31 patients who underwent an Oberlin transfer attained the same muscle strength and 80 percent of those patients (n=5) with median nerve to MCN regained MRC 3. The researchers did note that that the results of the following nerve transfers were not as encouraging: spinal accessory nerve to MCN (24 percent, N=45); phrenic nerve to MCN (17 percent, N=6); and intercostal to MCN (zero percent, N=2).

"The most important results we found in our evaluation was the significantly better outcome for the Oberlin procedure and the transfer of pectoral nerve to musculocutaneous nerve in contrast to transfer of spinal accessory nerve or phrenic nerve to musculocutaneous nerve," said Julia Oberhoffer, MD. "The reason for the huge advantage of these two transfers is the fact that you can coapt the nerve in an end-to-end way, so the nerves have to pass just one suture. Another important finding is the refutation of the well-established opinion that a nerve reconstruction has to be done as soon as possible. It only makes a difference when the reconstruction is done later than 10 months after the damage. So as plexus brachialis palsies are often devastating injuries, it is essential for the improvement of the quality of life for these patients that they will be transferred to a neurosurgical department within the first six months after a trauma, so that the operation can be conducted within the first 10 months. Furthermore a transfer where the nerves can be coapted through an end-to-end suture should always be the preferred procedure."

Dr. Oberhoffer added that "there is still no adequate explanation why some of the transfers of spinal accessory nerve to musculocutaneous nerve lead to good results and why the majority of them could not achieve a reinnervation of biceps muscle. From my point of view the main important goal for the future research is the detection of the differences between a successful outcome and a failed one to be able to appraise the operational outcome."

Disclosure: The author reported no conflicts of interest.

Media Representatives: The 2013 AANS Annual Meeting Press Kit includes releases on highlighted scientific research, AANS officer and award winners, National Neurosurgery Awareness Week, and other relevant information about this year''s program. Those releases also will be posted under the Media area on the 2013 AANS Annual Scientific Meeting website If you have interest in a topic related to neurosurgery or would like to interview a neurosurgeon - either on-site or via telephone - during this year''s event, please contact John Iwanski, AANS Director of Member and Public Outreach, via the onsite press room at (504) 670-4910 or e-mail him at jai@aans.org.

About the 2013 AANS Annual Scientific Meeting: Attended by neurosurgeons, neurosurgical residents, medical students, neuroscience nurses, clinical specialists, physician assistants, allied health professionals and other medical professionals, the AANS Annual Scientific Meeting is the largest gathering of neurosurgeons in the nation, with an emphasis on the field''s latest research and technological advances. A record-breaking 1,003 scientific abstracts were presented for review at the 2013 AANS Annual Scientific Meeting, and the scientific presentations given at this year''s event represent cutting-edge examples of the incredible developments taking place within the field of neurosurgery. Additional information about the AANS Annual Scientific Meeting and the Meeting Program can be found at Annual Meeting.

Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with nearly 8,300 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. All active members of the AANS are certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons (Neurosurgery) of Canada or the Mexican Council of Neurological Surgery, AC. Neurological surgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the entire nervous system including the spinal column, spinal cord, brain and peripheral nerves. For more information, visit AANS.org

Source: Newswise

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