Managing obesity is difficult, as many patients rebound to their pre-treatment weight. Obesity is a chronic metabolic disorder that affects half a billion people worldwide. There is a hypothesis that chronic weight gain causes the body to adopt a state that supports excess weight. In a study published in the Journal of Clinical Investigation, researchers led by Malcolm Low at the University of Michigan challenged this hypothesis by developing a mouse model of obesity where the proopiomelanocortin (Pomc) gene in the hypothalamus can be turned on and off. With Pomc turned off, the mice ate heavily and became obese. Low and colleagues turned Pomc back on at different time points after the mice became obese and found that the effectiveness of this genetic rescue declined as the longer the mice stayed obese. In a companion commentary, Joel Elmquist of the University of Texas Southwestern Medical Center discusses the impact of this research on the development of strategies to halt the obesity epidemic. Source: Eurekalert << World's Oldest Writing Nearly Decoded Role Of LncRNAs In Heritable Human Diseases >> Recommended Reading Malnutrition to Obesity - The Big Leap Obesity is the root cause of problems like diabetes, heart disease, stroke, arthritis and gall bladder disease. A serious look at our strategies is needed to tackle this fast growing epidemic. READ MORE Obesity Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults. READ MORE Child Obesity Linked To Presence Of Electronics In Bedroom TVs, computers, video games and cellphones- children with one or more electronic devices in the bedroom are far more likely to be overweight or obese, a new research has warned. READ MORE Obesity May Contribute To Cancer Growth A new link between cancer and obesity has been found by Investigators at The University of Texas Health Science Center at Houston (UTHealth). READ MORE Battle of the Bulge The ‘battle of bulge’ is the toughest of all battles. Once you put on weight it is so difficult to get rid of it. Here are the best tips to fight off that extra flab. READ MORE Bulimia Nervosa The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followed by self-induced vomiting or purgation. READ MORE Carbohydrates and Its Role in Obesity Obesity is a global epidemic with majority of the world’s population in developed countries being over weight or obese! READ MORE Diabesity With more than one billion people affected, diabesity is the largest epidemic in the world today. Fortunately it can be reversed with lifestyle changes. READ MORE Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages Sugar-sweetened beverages contribute to metabolic syndrome leading to higher risk for type-2 diabetes and cardiovascular disease. READ MORE Diet and Nutrition for Healthy Weight Loss Correct diet and a planned exercise regime is the mantra of healthy and sustainable weight loss. READ MORE Hunger Fullness and Weight Control An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the major causes of obesity. READ MORE Liposuction Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition to give a well-contoured shapely look. READ MORE Most Popular on Medindia Iron Intake Calculator Blood - Sugar Chart Indian Medical Journals More News on: Bariatric SurgeryObesityBulimia NervosaLiposuctionBattle of the BulgeDiabesityHunger Fullness and Weight ControlDiet and Nutrition for Healthy Weight LossDiabetes Type 2 and Its Link to Sugar-Sweetened BeveragesCarbohydrates and Its Role in Obesity
Managing obesity is difficult, as many patients rebound to their pre-treatment weight. Obesity is a chronic metabolic disorder that affects half a billion people worldwide. There is a hypothesis that chronic weight gain causes the body to adopt a state that supports excess weight. In a study published in the Journal of Clinical Investigation, researchers led by Malcolm Low at the University of Michigan challenged this hypothesis by developing a mouse model of obesity where the proopiomelanocortin (Pomc) gene in the hypothalamus can be turned on and off. With Pomc turned off, the mice ate heavily and became obese. Low and colleagues turned Pomc back on at different time points after the mice became obese and found that the effectiveness of this genetic rescue declined as the longer the mice stayed obese. In a companion commentary, Joel Elmquist of the University of Texas Southwestern Medical Center discusses the impact of this research on the development of strategies to halt the obesity epidemic. Source: Eurekalert << World's Oldest Writing Nearly Decoded Role Of LncRNAs In Heritable Human Diseases >> Recommended Reading Malnutrition to Obesity - The Big Leap Obesity is the root cause of problems like diabetes, heart disease, stroke, arthritis and gall bladder disease. A serious look at our strategies is needed to tackle this fast growing epidemic. READ MORE Obesity Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults. READ MORE Child Obesity Linked To Presence Of Electronics In Bedroom TVs, computers, video games and cellphones- children with one or more electronic devices in the bedroom are far more likely to be overweight or obese, a new research has warned. READ MORE Obesity May Contribute To Cancer Growth A new link between cancer and obesity has been found by Investigators at The University of Texas Health Science Center at Houston (UTHealth). READ MORE Battle of the Bulge The ‘battle of bulge’ is the toughest of all battles. Once you put on weight it is so difficult to get rid of it. Here are the best tips to fight off that extra flab. READ MORE Bulimia Nervosa The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followed by self-induced vomiting or purgation. READ MORE Carbohydrates and Its Role in Obesity Obesity is a global epidemic with majority of the world’s population in developed countries being over weight or obese! READ MORE Diabesity With more than one billion people affected, diabesity is the largest epidemic in the world today. Fortunately it can be reversed with lifestyle changes. READ MORE Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages Sugar-sweetened beverages contribute to metabolic syndrome leading to higher risk for type-2 diabetes and cardiovascular disease. READ MORE Diet and Nutrition for Healthy Weight Loss Correct diet and a planned exercise regime is the mantra of healthy and sustainable weight loss. READ MORE Hunger Fullness and Weight Control An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the major causes of obesity. READ MORE Liposuction Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition to give a well-contoured shapely look. READ MORE Most Popular on Medindia Iron Intake Calculator Blood - Sugar Chart Indian Medical Journals More News on: Bariatric SurgeryObesityBulimia NervosaLiposuctionBattle of the BulgeDiabesityHunger Fullness and Weight ControlDiet and Nutrition for Healthy Weight LossDiabetes Type 2 and Its Link to Sugar-Sweetened BeveragesCarbohydrates and Its Role in Obesity
