About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Early Brain Changes Noticed in Healthy Children of Alzheimer Patients

by Rajashri on July 31, 2008 at 3:10 PM
Font : A-A+

 Early Brain Changes Noticed in Healthy Children of Alzheimer Patients

Researchers at the Medical College of Wisconsin in Milwaukee reveal that Washington, healthy children of Alzheimer patients display neurological changes much before clinical symptoms may appear.

By using functional MRI brain imaging, the researchers found that these symptomless carriers of the APOE-4 gene demonstrated significantly reduced functional brain connectivity between the hippocampus and the posterior cingulated cortex, two important brain structures for memory processing.

Advertisement

These structures are relevant for information acquisition, filtering and sorting

Led by Shi Jiang Li, Ph.D., professor of biophysics, this study was conducted at Froedtert Hospital.

"Just as if cancer could be detected when there were only a few cells, decades before it was evident, the advantage of identifying those at great risk for having Alzheimer's would be of tremendous value in development of interventional therapies," said Dr. Li.
Advertisement

In the study, the researchers examined 28 neurologically-normal subjects, between ages 45 and 65. Out of these, 12 carried the APOE-4 gene and 16 did not.

No significant difference in age, educational level, or neuropsychological performances was seen in the two groups. All subjects received fMRI scans. For each subject, functional connectivity between the two brain structures was measured in a resting state.

It was revealed that functional connectivity in the non APOE-4 carriers was approximately 65 percent better than that of the carriers.

The study was presented at the Alzheimer's Association International Conference on Alzheimer's disease in Chicago.

Source: ANI
RAS/L
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alzheimers Disease Parkinsons Disease Parkinsons Disease Surgical Treatment Height and Weight-Kids Brain Brain Facts Ataxia Creutzfeldt-Jakob Disease Language Areas in The Brain Healthy Gifting Ideas for Diwali 

Recommended Reading
Alzheimers Disease
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and ......
The Lancet Says Dementia in Developing World 'Substantially' Underestimated
A new study, led by researchers from King's College London, has shown that cases of dementia in the ...
Dysfunctional Transporters in Nerves Linked to Alzheimer's
New research from NYU Langone Medical Center presents membrane vesicles, which are essential for ......
Amyloid Plays an Important Role in Memory
Scientists at NYU Langone Medical Center have discovered that the beta amyloid peptide - which ......
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Creutzfeldt-Jakob Disease
Creutzfeldt-Jakob disease (CJD) is a rare form of degenerative brain disorder, or brain damage that ...
Healthy Gifting Ideas for Diwali
Diwali, the festival of lights is round the corner. Take a fat free route when it comes to gifting t...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use