About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Drug to Treat Heavy Bleeding may Prevent Maternal Deaths

by Megha Ramaviswanathan on January 30, 2018 at 11:35 AM
Font : A-A+

Drug to Treat Heavy Bleeding may Prevent Maternal Deaths

Tranexamic acid prevents blood loss after vaginal births and postpartum hemorrhage (PPH-major blood loss after labor and birth) among women who have an operative vaginal delivery (use of a vacuum or forceps) or an episiotomy (surgical cut made at the opening of the vagina during childbirth), finds a study. The study will be presented at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting.

Postpartum hemorrhage (PPH), the leading cause of maternal deaths worldwide accounts for approximately one-quarter of all maternal deaths. In the United States, about 3.1% of births occur via operative vaginal delivery and 11-12% of births include an episiotomy. These rates may vary between low, middle and high-income countries.

Advertisement


Tranexamic acid (TXA) has long been used to reduce bleeding in elective surgeries, trauma patients, and menstrual blood loss. More recently, TXA has been recommended for the treatment of PPH and studied for use following cesarean birth. However, until now, there were no methodically sound studies that demonstrated TXA could prevent PPH in vaginal births. The research presented is part of the "TRAnexamic Acid for Preventing Postpartum Hemorrhage after Vaginal Delivery," more commonly referred to as the TRAAP Trial.

In multicenter, randomized control study in France, scientists gave nearly 4,000 women in labor either one gram of TXA or a placebo. In the group that received the TXA, there was a reduction in the incidence of postpartum blood loss. In sub-group analysis, the researchers found that TXA reduced PPH in women with instrumental vaginal delivery and episiotomy. Further, there was no increase in severe adverse events in the TXA group, including thrombotic events, as compared to the placebo group in the three months after delivery.
Advertisement

"TXA should be considered for women who deliver via operative vaginal delivery and episiotomy in conjunction with prophylactic oxytocin," said Loc Sentilles, MD, PhD, lead author of the study and chair of the Department of Obstetrics and Gynecology at Bordeaux University Hospital. "At the dosage studied, the only side effect observed was an increase in nausea and vomiting."

There are certain risk factors that increase the likelihood of a woman experiencing PPH, including obesity, prolonged or augmented labor, previous cesarean birth, and others. However, more women with PPH have no identifiable risk factors. Therefore, it is therefore essential to prevent PPH and ultimately save women's lives.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Coffee May Help You Fight Endometrial Cancer
Fermented Skin Care
Television Binge-Watching May Boost the Risk of Deadly Blood Clots
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Menorrhagia von Willebrand Disease Drugs Banned in India Hemophilia Maternal Death 

Recommended Reading
Postpartum Hemorrhage
Excessive hemorrhage after delivering a baby can be an emergency, leading to shock and even death .....
To Reduce Maternal Mortality Doctors Favor Low-cost Devices
Low-cost devices favored by specialist doctors to reduce maternal mortality and ensure better ......
LifeWrap Garments Prevent Postpartum Hemorrhage and Maternal Mortality
Every year, at least 70,000 women die from obstetric hemorrhage - mostly in the world's least ......
Obstetric Hemorrhage Reduced With Maternal Safety Toolkits
Obstetric hemorrhage is the leading cause of severe maternal morbidity and preventable maternal ......
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Hemophilia
Hemophilia is a rare single gene, X- linked disorder, which tends to run in families....
Maternal Death
Maternal mortality or maternal death refers to the death of a woman occurring during her pregnancy o...
Menorrhagia
Menorrhagia is a condition where a woman has menstrual periods that are heavy or prolonged and cause...
von Willebrand Disease
von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)