In aged mice, a promising new drug that proven to significantly increase muscle size, strength and metabolic state discovered by researchers from The University of Texas Medical Branch at Galveston. The findings of the study are published in Biochemical Pharmacology.
As we age, our bodies increasingly lose the ability to repair and rebuild degenerating skeletal muscles. Beginning around age 35, muscle mass, strength and function continually decline as we get older. This can dramatically limit the ability of older adults to live fully active and independent lives.
"We identified a protein in muscle stem cells that appears to be responsible for their age-related dysfunction, and then developed a small molecule drug that limits the effects of this protein," said senior author Stanley Watowich, UTMB associate professor in the department of biochemistry and molecular biology. "By resetting muscle stem cells to a more youthful state, we were able to rejuvenate them so that they could more effectively repair muscle tissues."
Adults over 65 are the fastest growing segment of the population in many countries. Much of this spending will be used to treat health problems related to muscle decline, including hip fractures, falls and heart disease.
"There are no treatments currently available to delay, arrest or reverse age-related muscle degeneration," said senior author Harshini Neelakantan, a UTMB research scientist in the department of biochemistry and molecular biology. "These initial results support the development of an innovative drug treatment that has the potential to help the elderly to become fitter, faster and stronger, thus enabling them to live more active and independent lives as they age."