About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Drug Increases Breast Cancer Risk for Vulnerable Women

by Bidita Debnath on December 13, 2013 at 11:42 PM
Font : A-A+

 Drug Increases Breast Cancer Risk for Vulnerable Women

Researchers reported in the Lancet that post-menopausal women with a family history of breast cancer are at the risk of developing the disease by taking an anti-hormone drug called anastrozole.

Doctors at Queen Mary University in London found a reduction in risk of 53 percent among volunteers who took the drug for five years, compared to counterparts who took a harmless lookalike called a placebo.

Advertisement

Anastrozole is not only more effective than the two standard drugs for preventing breast-cancer, tamoxifen and raloxifene, it also has fewer side effects, they added.

The study enrolled 3,864 post-menopausal women considered to have a high inherited risk of breast cancer.

They were deemed to be in this category if they had had two or more blood relatives with breast cancer, had a mother or sister who developed breast cancer before the age of 50 or had a mother or sister who had cancer in both breasts.
Advertisement

At the followup-point, five years after enrolment, 40 women in the anastrozole group had developed breast cancer compared to 85 women in the placebo group.

"This research is an exciting development in breast cancer prevention. We now know anastrozole should be the drug of choice when it comes to reducing the risk of breast cancer in post-menopausal women with a family history or other risk factors for the disease," said Jack Cuzick, head of the university's Centre for Cancer Prevention.

"This class of drugs is more effective than previous drugs such as tamoxifen and crucially, it has fewer side effects."

Side effects were rare, mostly comprising small increases in muscle aches and pains, and hot flashes, according to Cuzick.

"Our priority now is ensuring that as many women as possible can benefit from these new findings," he said.

Anastrozole, marketed under the brand name Arimidex, works by preventing the body from making the hormone oestrogen, a source for many breast cancers.

It has been used for more than 10 years to treat postmenopausal women diagnosed with so-called oestrogen receptor positive breast cancer.

In a press release, the British charity Cancer Research UK, which helped fund the research, said the study was a "landmark."

The next step was to determine which women benefited most from the drug, and which were likely to have the least side effects from taking it for a prolonged period, it said.

Cuzick added that the researchers intended to follow the volunteers for "at least 10 years, and hopefully much longer," to see whether the preventative effect was sustained, and to monitor for any change in side-effects.

The study was simultaneously presented on Thursday at a conference on breast cancer in San Antonio, Texas.



Source: AFP
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Link between Dietary Intake of Plant-based Essential Fatty Acids and Death Risk
Aspirin may be Harmful When Used for Preventing 1st Heart Attack, Stroke
Pregnancy Complications Elevated Among Symptomatic COVID-19 Women
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Drug Toxicity Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Signature Drug Toxicity Breast Cancer Facts Cancer Facts Cancer 

Recommended Reading
Some Older Patients With Breast Cancer can Opt to Avoid Radiotherapy
Results of the PRIME 2 trial presented at the 2013 San Antonio Breast Cancer Symposium reveal that ....
Combined Therapy Connected to Reduced Recurrence in Women With Small, HER2+ Breast Cancers
In a new study, women with relatively small, HER2-positive breast tumors who received a combination ...
Women With HER2-positive Breast Cancer Benefited With Chemotherapy and Trastuzumab
Women with HER2-positive breast cancer who had the highest levels of immune cells in their tumors .....
Exercise Protects Against Aggressive Breast Cancer in Black Women, Says Study
Regular vigorous exercise reduces the risk of aggressive breast cancer in black women, says study....
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use