‘Pediatric dosage guidelines are based on weight-based formulas, available dosing formulations, and prior patterns of use.
The analysis also found that it is common to find two or more-fold variation in the doses suggested in the guidelines from doses predicted by allometric scaling--which considers a dose for children to be a partial adult dose, dependent on variable factors of age, height, and weight. Arbitrary large shifts in recommended doses at certain age limits were also common within the guidelines.
"The increasing focus on pediatric dosing is a positive development, especially with the development of pediatric-focused formularies in the last decade. However, there is still a lot of room for improvement," said lead author Dr. Kate Chitty, of The University of Sydney, in Australia.