About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

DNA-based Nanogel Helps Provide Targeted Chemotherapy

by Angela Mohan on November 20, 2020 at 10:55 AM
Font : A-A+

DNA-based Nanogel Helps Provide Targeted Chemotherapy

DNA-based nanogels break down and release their drug contents within cancer cells, reducing the effects on normal cell and thereby side effects, as per the study in ACS' Nano Letters.

Once ingested or injected, chemotherapy medications move throughout the body, indiscriminately affecting healthy cells along with those that are responsible for disease.

Advertisement


Since many of these drugs are toxic to all cells, the desired tumor shrinkage can be accompanied by undesirable side effects, such as hair loss, gastrointestinal issues and fatigue.

Nanogels made of DNA are one way that these drugs could be delivered, but they would still enter all cells. Tianhu Li, Teck-Peng Loh and colleagues reasoned that biomarkers -- proteins or other components that are present in differing amounts in cancer cells and their healthy counterparts -- could play a role in breaking down a nanogel, causing it to release its contents only in those that are cancerous.
Advertisement

A biomarker called FEN1, a repair enzyme that cuts certain types of DNA, is present in larger amounts in cancer cells compared with healthy ones. The researchers wanted to see whether they could design a DNA nanogel that would specifically be degraded in cancer cells by FEN1.

To make DNA nanogels, the researchers used special DNA structures that FEN1 could recognize and cut. With cell-free systems, the researchers observed that the DNA-based nanogels were broken down by FEN1 but not by other DNA repair enzymes or compounds.

When live cells were incubated with the DNA-based nanogels, healthy ones did not have enough FEN1 to break them down, but cancer cells did. When the chemotherapeutic drugs doxorubicin and vinorelbine were incorporated into the nanogel, human breast cancer cells died at higher rates than normal, healthy breast cells.

These findings indicate DNA-based nanogels can introduce drugs into cancer cells with a high specificity, reducing the risk of side effects. The researchers say that the nanogels also could be used as probes for the biomarker enzyme, helping physicians more directly diagnose cancer compared with current methods.

The authors acknowledge funding from Northwestern Polytechnical University in China and the Agency for Science, Technology and Research in Singapore.

The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS' mission is to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and its people.

The Society is a global leader in providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, eBooks and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research.

As a specialist in scientific information solutions (including SciFinder� and STN�), its CAS division powers global research, discovery and innovation. ACS' main offices are in Washington, D.C., and Columbus, Ohio.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Prevent Hacking of Medical Devices: FDA Sounds Alarm
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Peritoneal Cancer Rhabdomyosarcoma Male Breast Cancer Tumor Lysis Syndrome Neutropenic Sepsis 

Most Popular on Medindia

Nutam (400mg) (Piracetam) Diaphragmatic Hernia Find a Hospital Post-Nasal Drip Hearing Loss Calculator Sanatogen Color Blindness Calculator Accident and Trauma Care Noscaphene (Noscapine) Iron Intake Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use