Contrary to expectations, diets high in the nutrient choline were associated with an increased risk of some colorectal polyps, which can—but do not always—lead to colorectal cancer, according to a study. Major food sources of choline include red meat, eggs, poultry, and dairy products. Choline is involved in a biochemical process known as one-carbon metabolism. Studies have shown that people with increased intake of other nutrients required for one-carbon metabolism, such as folate, are at a decreased risk for colorectal polyps. This is the first study to examine the association between choline and colorectal polyps. Eunyoung Cho, Sc.D., of Brigham and Women's Hospital in Boston and colleagues sent food-frequency questionnaires to women enrolled in the Nurses' Health Study every two to four years from 1984 to 2002. They then estimated the choline content in their diets. The researchers had hypothesized that choline intake would decrease the risk of colorectal polyps like folate does. But the results suggest the opposite—greater amounts of choline in the diet were associated with an elevated risk of colorectal polyps. "Although our results were contrary to expectation based on choline's role [in one-carbon metabolism], there is a potential biologic basis for the positive association that we observed...Once a tumor is initiated, growth into a detectable [polyp] depends in part on choline availability because choline is needed to make membranes in all rapidly growing cells," the authors write. However, because this was the first study of choline and colorectal polyps, and other components of diets high in choline may be responsible for the association, the finding needs to be replicated in other studies. In an accompanying editorial, Regina Ziegler, Ph.D., and Unhee Lim, Ph.D., of the National Cancer Institute in Bethesda, Md., describe the complexity of the relationship between one-carbon metabolism and the development of cancer. "Clearly, one-carbon metabolism and its role in [cancer development] is more complicated than originally anticipated, and our understanding of the underlying mechanisms is probably incomplete. More research, and caution in developing public health policy and guidance, is warranted," the authors write. Source: EurekalertLIN/J << Every Saturday is 'Environment Day' for Chandigarh Kids Indian Experts Joining Hands With Global to Reduce Greenhous... >> Recommended Reading Atkins Diet Atkins diet is a low carbohydrate diet and aids in weight loss. It was developed by Robert Atkins. READ MORE Hunger Fullness and Weight Control An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the major causes of obesity. READ MORE Is a Vegetarian Diet Safe During Pregnancy? Great care must be taken with diet during pregnancy for the baby’s healthy development. Being vegetarian is not a minus but dietary recommendations must be followed closely for a healthy pregnancy. READ MORE Lifestyle Modification: No Big Deal! Simple and practically possible lifestyle changes can make a huge difference in improving our health status without actually putting much effort. READ MORE Low Carbohydrate Diet A low carbohydrate diet helps achieve weight loss. It is a diet plan that restricts the carbohydrate intake. READ MORE Macrobiotic Diet Macrobiotics is an Oriental theory that lays down guidelines for promoting well-being and longevity through systematic diet consisting mainly of whole grains and beans. READ MORE South Beach Diet South Beach Diet plan originally developed to prevent heart disease, soon gained popularity as weight loss diet plan. This diet plan was developed by Dr.Arthur Agaston and Marie Almon. READ MORE Top Diet Foods that Make you Fat Every nutrition fad comes with its share of diet foods. While they seem healthy, many diet foods promote weight gain. This article will highlight the top diet foods that make you fat. READ MORE Weight Loss with Hypnosis – Does It Work? Hypnosis indirectly helps with weight loss by altering the consciousness through suggestions and imagery to a more positive state. READ MORE Most Popular on Medindia Diaphragmatic Hernia Blood Donation - Recipients Pregnancy Confirmation Calculator More News on: Low Carbohydrate DietAtkins DietSouth Beach DietMacrobiotic DietLifestyle Modification: No Big Deal!Hunger Fullness and Weight ControlWeight Loss with Hypnosis – Does It Work?Quiz on Weight LossTop Diet Foods that Make you FatIs a Vegetarian Diet Safe During Pregnancy?