About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Decreased Dopamine Activity in Brain Leads to ADHD in Adults

by VR Sreeraman on August 7, 2007 at 5:34 PM
Font : A-A+

Decreased Dopamine Activity in Brain Leads to ADHD in Adults

A new study has linked Attention Deficit Hyperactivity Disorder (ADHD) in adults with depressed dopamine activity in the brain. The study showed a blunted response to the drug methylphenidate (Ritalin), which increases brain dopamine levels in ADHA patients.

Dopamine is a phenethylamine naturally produced by the human body, which acts as a neurotransmitter in the brain.

Advertisement

The study was conducted by a team of researchers led by Nora D. Volkow at the National Institute on Drug Abuse, Bethesda, Maryland.

As part of the study, researchers examined 19 adults with with ADHD (average age 32) who had never received medication and 24 healthy controls (average age 30) and performed brain scans using positron emission tomography (PET) and a drug known as raclopride labelled with carbon 11 ([11C]raclopride), which binds with dopamine receptors.
Advertisement

Researchers scanned the patients twice after injecting them with placebo and methylphenidate. The participants were asked to report the severity of their ADHD symptoms, whether they could detect the drug, if they liked or disliked it, and if it made them feel 'high', tired, alert, anxious or restless.

The study found that methylphenidate caused less of a decrease in the amount of [11C]raclopride that bound to dopamine receptors in areas of the brain associated with attention in individuals with ADHD.

Researchers suggested that since levels of methylphenidate in the blood were same in both groups, those with ADHD released less dopamine in response to the drug than controls. This blunted response was associated with symptoms of inattention.

"The findings of reduced dopamine release in subjects with ADHD are consistent with the notion that the ability of stimulant medications to enhance extracellular dopamine underlies their therapeutic effects in ADHD," the authors wrote.

The findings of the study were published in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Source: ANI
LIN/J
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Dyslexia Attention Deficit Hyperactivity Disorder (ADHD) Parkinsons Disease Parkinsons Disease Surgical Treatment Bullying at School - Tips For Schools Brain ADHD Dyscalculia / Learning Disabilities Brain Facts Ataxia 
Recommended Reading
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder that affects normal be...
Dyscalculia / Learning Disabilities
Dyscalculia is a learning disability involving mathematics. Recognized by The WHO, it affects nearl...
Dyslexia
Dyslexia is a reading disability that occurs when the brain does not properly recognize and process ...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use