Damage Caused by Heart Attack can be Slashed to Half Through Microparticle Therapy

by Kathy Jones on  January 17, 2014 at 11:26 PM Heart Disease News
RSS Email Print This Page Comment bookmark
Font : A-A+

A joint study conducted by researchers at Northwestern Medicine and University of Sydney suggests that injecting microparticles into the blood stream within 24 hours of a heart attack can cut down the inflammatory damage to heart muscle by as much as half.
 Damage Caused by Heart Attack can be Slashed to Half Through Microparticle Therapy
Damage Caused by Heart Attack can be Slashed to Half Through Microparticle Therapy

When biodegradable microparticles were injected after a heart attack, the size of the heart lesion was reduced by 50 percent and the heart could pump significantly more blood.

"This is the first therapy that specifically targets a key driver of the damage that occurs after a heart attack," said investigator Daniel Getts, a visiting scholar in microbiology-immunology at Northwestern University Feinberg School of Medicine. "There is no other therapy on the horizon that can do this. It has the potential to transform the way heart attacks and cardiovascular disease are treated."

The micoparticles work by binding to the damaging cells -- inflammatory monocytes -- and diverting them to a fatal detour. Instead of racing to the heart, the cells head to the spleen and die.

The particles are made of poly (lactic-co-glycolic) acid, a biocompatible and biodegradable substance already approved by the Food and Drug Administration for use in re-absorbable sutures. A microparticle is 500 nanometers, which is 1/200th size of a hair.

The scientists' study showed the microparticles reduced damage and repaired tissue in many other inflammatory diseases. These include models of West Nile virus, colitis, inflammatory bowel disease, multiple sclerosis, peritonitis and a model that mimics blood flow after a kidney transplant.

"The potential for treating many different diseases is tremendous," said investigator Stephen Miller, the Judy Gugenheim Research Professor at Feinberg. "In all these disease models, the microparticles stop the flood of inflammatory cells at the site of the tissue damage, so the damage is greatly limited and tissues can regenerate."

Getts, Miller and Nicholas King, professor of viral immunopathology at the University of Sydney School of Medical Sciences, are corresponding authors on the paper, which will be published January 15 in Science Translational Medicine.

Biotech Startup Aims for FDA Approval and Clinical Trial

The Northwestern and University of Sydney results are so encouraging, the scientists have partnered with a startup biotechnology company, Cour Pharmaceutical Development Co., to produce a refined version of the microparticles in anticipation of what they hope will be a clinical trial in myocardial infarction (heart attack) within two years. The company plans to submit an investigational new drug application to the FDA.

"This discovery has the potential to transform how inflammatory disorders are treated and the use of microparticles derived from biodegradable polymers means that this therapy could be rapidly translated for clinical use," said John Puisis, the chief executive officer of Cour.

How a Fatal Attraction Saves the Heart

The microparticles are designed to have a negative charge on their surface. This makes them irresistible to the inflammatory monocytes, which have a positively charged receptor. It's a fatal attraction. When the inflammatory cell bonds to the microparticle, a signal on the cell is activated that announces it's dying and ready for disposal. The cell then travels to the spleen, the natural path for the removal of dying cells, rather than going to the site of the inflammation.

"We're very excited," King said. "The potential for this simple approach is quite extraordinary. Inflammatory cells pick up immune-modifying microparticles and are diverted down a natural pathway used by the body to dispose of old cells.

It's amazing that such a simple detour limits major tissue damage in such a wide range of diseases."

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Chest Pain Cardiac Catheterization Heart Attack Diet Lifestyle and Heart Disease Coronary Artery Bypass Grafting Reiki and Pranic Healing Stress and the Gender Divide Heart Attack Facts Heart Heart Attack- Lifestyle Risks 

News A - Z


News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive