About Careers MedBlog Contact us

Coming Soon, Cure to Drug-resistant Tuberculosis!

by Mansi Shroff on February 25, 2015 at 2:31 PM
Font : A-A+

 Coming Soon, Cure to Drug-resistant Tuberculosis!

A team of scientists have discovered a potential treatment for drug-resistant tuberculosis, a form of the disease that cannot be cured with conventional therapies.

While standard anti-TB drugs can cure most people of Mycobacterium tuberculosis infection, improper use of antibiotics has led to new strains of the bacterium resistant to the two most powerful medications, isoniazid and rifampicin.


Lead author Vasu Nair from the University of Georgia said that multi-drug resistant TB is spreading rapidly in many parts of the world and there is a tremendous need for new therapies, and they think their laboratory has developed a strong candidate that disrupts fundamental steps in the bacterium's reproduction process.

The compound, which works by binding to magnesium and specific amino acids found within the bacterium, interrupting the production of RNA, strongly inhibits the growth of the bacterium and renders it incapable of reproducing and spreading infection and shows very low levels of cytotoxicity, which means that it is not harmful to the body, said Nair.

Nair added that all their tests were very favorable. The half-life is a little over 14 hours and all traces of the drug are expected to be cleared through normal bodily functions.

Researchers also discovered through preliminary experiments that it also exhibited strong anti-HIV properties, opening the door for dual therapeutic applications.

Nair concluded that this discovery of dual activity against both retroviruses and drug-resistant gram-positive bacteria is unique and opens a new chapter in drug discovery in this area.

The study appears in Bioorganic and Medicinal Chemistry Letters.


Latest Drug News

 Parkinson's Unmet Needs Creates Path for New Entrants into the Market
Addressing the unmet needs of Parkinson's Disease by providing disease-modifying therapies could bring about a major shift in the way that patients are treated.
How Microrobots Could Help Treat Bladder Diseases?
Microrobots could swirl through a person's blood stream, search for targeted areas to treat for various ailments.
How Can Multivitamin Supplements Slow Cognitive Aging?
Supplementation with multivitamins is an inexpensive way for older adults to slow down memory loss.
 Ivosidenib Approved for Acute Myeloid Leukemia & Advanced Cholangiocarcinoma
Some people with an aggressive blood cancer called acute myeloid leukemia (AML) may soon have a new drug option called Ivosidenib that blocks the activity of IDH1 gene.
Sacubitril/valsartan Unleashes Hope for Heart Failure Patients
In case of cardiac failure where the ejection fraction is greater than 40%, sacubitril/valsartan can prove to be quite beneficial
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Coming Soon, Cure to Drug-resistant Tuberculosis! Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests