![Cognitive Training Reduced Freezing of Gait (FoG) in Parkinson`s Patients Cognitive Training Reduced Freezing of Gait (FoG) in Parkinson`s Patients](https://images.medindia.net/health-images/1200_1000/gut-brain-connection-in-parkinsons-disease.jpg)
‘Cognitive training showed large and statistically significant reduction in FoG severity in patients with Parkinson’s disease.’
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Patients with Parkinson’s Disease who self-reported FoG and who were free from dementia were randomly allocated to receive either a cognitive training intervention or an active control.
Sixty-five patients were randomized into the study. The sample of interest included 20 patients randomly assigned to the cognitive training intervention and 18 randomized to the active control group.
Both groups were clinician-led and conducted twice-weekly for seven weeks. The primary outcome was the percentage of time spent frozen during a ’Timed Up and Go’ task, assessed while patients were both on and off dopaminergic medications.
Secondary outcomes included multiple neuropsychological and psychosocial measures, including assessments of mood, well-being and length and quality of sleep.
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The researchers report that patients in the cognitive training group showed a large and statistically significant reduction in FoG severity while on dopaminergic medication compared to participants in the active control group on dopaminergic medication.
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There was no difference between groups when they were tested without their regular dopaminergic medication.
"We believe there is reason to be hopeful for the use of these trials in the future," said study leader, Dr Simon Lewis, a professor of cognitive neuroscience at the University of Sydney’s Brain and Mind Centre and Royal Prince Alfred Hospital in Australia.
"The feedback we’ve had from participants and family members involved in this study was overwhelmingly positive. The results of this pilot study highlight positive trends, and the importance of nonpharmacological trials involving cognitive training has become increasingly clear."
The research team, comprising scholars from the University of Sydney, Western Sydney University and Cambridge University say the finding that freezing of gait improved only while patients were on dopaminergic medication is noteworthy.
"Taking dopaminergic medications as prescribed is the normal day-day state for patients with Parkinson’s Disease," said study lead-author, Dr Courtney Walton, formerly at the University of Sydney and now at the University of Queensland.
"While more research is needed to better understand and establish these findings, it’s likely that participants in the off- dopaminergic state were too impaired to benefit from any of the potential changes initiated through cognitive training."
The researchers say more studies using larger samples are needed to investigate this initial finding that cognitive training can reduce the severity of freezing of gait in Parkinson’s diseases patients.
Source-Eurekalert