These researchers speculated that the Pael-R gene is possibly involved in the action of rotenone on cells. Therefore, they investigated the role of the Pael-R gene in rotenone-induced Parkinson's disease model cells using RNA interference.
IN their recent study, Pael-R expression was decreased after RNA interference compared with the control group (no treatment) and the model group (rotenone treatment), while the rate of apoptosis and survival of dopaminergic cells did not differ significantly between groups. Experimental findings, published in the Neural Regeneration Research
(Vol. 9, No. 4, 2014), indicate that the Pael-R gene has no role in the changes in rotenone-induced Parkinson's disease model cells.