About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Cell Scaffolding Protein Fascin-1 Associated With Increased Risk of Metastasis

by Bidita Debnath on February 26, 2013 at 11:42 PM
Font : A-A+

 Cell Scaffolding Protein Fascin-1 Associated With Increased Risk of Metastasis

A meta-analysis finds that a protein involved in the internal cell scaffold is associated with increased risk of metastasis and mortality in a range of common cancers.

This meta-analysis is published in Biomed Central's open access journal BMC Medicine.

Advertisement

The protein, fascin-1, is involved in bundling together the actin filaments which form the internal scaffolding of a cell and are involved in cell movement. Though it is absent, or only present at a low level in normal epithelial cells, several small studies have shown fascin-1 to be increased in many carcinomas, but its role in metastasis and mortality risk has been uncertain.

Researchers from the University of Bristol combined and reanalysed data from 26 studies looking at five different types of carcinomas. The meta-analysis showed that increased fascin-1 was associated with increased risk of mortality in breast, colorectal and oesophageal carcinomas but not in gastric or lung carcinoma. It was also associated with disease progression in breast and colorectal carcinoma, but not lung carcinoma. It was associated with local and distant metastasis in colorectal and gastric carcinomas but there was no involvement of fascin-1 in metastasis of oesophageal carcinomas.
Advertisement

These results show that the picture is not simple and that different types of cancer are affected in different ways. The story of fascin-1 not only provides a biomarker and potential avenue for research into anti-cancer therapy but also demonstrates the complexity of cancer.

Josephine Adams and Richard Martin who led this study said, "Our results show that fascin-1 is associated with several types of human carcinomas. The results will help focus further research into fascin-1 as a marker and potential target for cancer therapy to the most relevant types of carcinomas."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment Magical Millets for Your Health Diet and Nutrition Tips for Athletes Nutrition IQ 

Recommended Reading
Breast Cancer - Prevention and Management with Lifestyle Changes
Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up ......
Bladder Cancer
Bladder Cancer affects the urinary bladder and can be superficial or deep type and this affects its ...
Bile Duct Cancer
Bile duct cancer occurs either within the liver or the point where the bile ducts emerge from the .....
Diet and Nutrition Tips for Athletes
Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mental...
Magical Millets for Your Health
Millets are far more nutrient dense than wheat and rice. They are inexpensive and tasty too. Nutriti...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use