The mechanism that leads to the development of ANCA-associated vasculitis has been discovered by the Vasculitis Experimental Animal-Based Research Working Group.
The team discovered that neutrophil extracellular traps (NETs) structures play a role in the activation of the complement system (which forms part of the immune system), thereby contributing to the development of the disease. Using a variety of genetically-modified animal models and a pharmacological model, the researchers were able to show that necroptosis is one of the key mechanisms of pathogenesis in the development of severe vasculitis which is also associated with severe renal involvement.
ANCA-associated vasculitis is a systemic disease, which is characterized by the body's immune system attacking structures present inside white blood cells, thereby causing inflammation within small blood vessels. While kidney involvement is common in vasculitis, and may lead to acute renal failure, the condition can also affect the lungs and other organs. Conventional treatment is based on suppressing the immune system. This treatment method stops disease progression, but is associated with severe side effects.
"The specific pharmacological inhibition of programmed cell death may one day constitute a new approach to the treatment of ANCA vasculitis," explains PD Dr. Schreiber. He adds: "The first clinical studies are underway, testing whether the inhibition of necroptosis may be suitable for general application. Looking ahead, we hope that, based on our data, it will be possible to develop a new treatment for ANCA vasculitis."