by VR Sreeraman on  August 17, 2009 at 1:38 PM Research News
 Cannabis can Help Prevent Osteoporosis in Elderly
Cannabis may reduce bone strength in the young, and could also protect against osteoporosis, a weakening of the bones, in later life, a new study has found.

In the study, researchers looked at the effects of cannabis on bones, and have found its impact varies dramatically with age.

The results were uncovered by a team at the University of Edinburgh who compared the drug's effects on mice.

The research team showed that a molecule found naturally in the body, which can be activated by cannabis - called the type 1 cannabinoid receptor (CB1) - is key to the development of osteoporosis.

It is known that when CB1 comes into contact with cannabis it has an impact on bone regeneration, but until now it was not clear whether the drug had a positive or negative effect.

Researchers investigated this by studying mice that lacked the CB1 receptor. The scientists then used compounds - similar to those in cannabis - that activated the CB1 receptor. They found that compounds increased the rate at which bone tissue was destroyed in the young.

The study also showed, however, that the same compounds decreased bone loss in older mice and prevented the accumulation of fat in the bones, which is known to occur in humans with osteoporosis.

The study has been published in Cell Metabolism.

Stuart Ralston, the Arthritis Research Campaign Professor of Rheumatology at the University of Edinburgh, who led the study, said: "This is an exciting step forward, but we must recognise that these are early results and more tests are needed on the effects of cannabis in humans to determine how the effects differ with age in people.

"We plan to conduct further trials soon and hope the results will help to deliver new treatments that will be of value in the fight against osteoporosis."

Source: ANI

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