Cannabis abuse (CA) alters the activity of brain regions linked to negative emotion. It is associated with psychopathology, including negative emotionality and a higher risk of psychosis, particularly with early age of initiation.
The alterations were most pronounced in people who started using cannabis at a young age. The findings reveal potential negative long-term effects of heavy cannabis use on brain function and behavior, which remain largely unknown despite the drug's wide use and efforts to legalize the substance.
The study at the National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, assessed resting brain activity data from the Human Connectome Project of 441 young adults, and compared a smaller set of 30 people who met criteria for cannabis abuse with 30 controls. People with heavy cannabis use had abnormally high connectivity in brain regions important for reward processing and habit formation. The same regions have also been pegged in the development of psychosis in previous research.
The brain alterations were also associated with heightened feelings of negative emotionality, especially alienation, where one feels a sense of hostility or rejection from others. The link points to a potential biological mechanism for why feelings of alienation are often profoundly increased in people with cannabis dependence.