Marijuana can disrupt fertility in males, but it can also be a therapeutic strategy for treating male infertility.

‘Cannabinoid receptor or CB2 activator showed an acceleration of spermatogenesis, which may help in development of newer treatments for male infertility.
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To make their discovery, Grimaldi and colleagues treated three groups of mice with different agents for 14 to 21 days. The first group was treated with a specific activator of the CB2 receptor. The second group was treated with a specific inhibitor of the CB2 receptor. The third group received only a saline solution and served as the control group. 




The group treated with the CB2 activator showed an acceleration of spermatogenesis, while the group treated with the inhibitor displayed a slower rate of the process. This suggests that a tight balance of CB2 activation is required for the proper progression of spermatogenesis.
"That the normal beneficial effects of endogenous cannabinoids on spermatogenesis can be stimulated further by a chemical mimic, an agonist, is a potentially promising new idea for treating male infertility," said Thoru Pederson, Editor-in-Chief of The FASEB Journal.
Source-Eurekalert