Researchers say that women who develop tenderness in their breasts after using hormone replacement therapy are at an increased risk of developing breast cancer.
However, it is still unknown why breast tenderness indicates increased cancer risk among women on estrogen plus progestin hormone replacement therapy.
Hormone Replacement Therapy - Side effects and Risks
Prolonged use of HRT for more than 10 years can enhance risk of breast and uterine cancer.
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"Is it because the hormone therapy is causing breast-tissue cells to multiply more rapidly, which causes breast tenderness and at the same time indicates increased cancer risk? We need to figure out what makes certain women more susceptible to developing breast tenderness during hormone therapy than other women," said Dr. Carolyn J. Crandall, a clinical professor of general internal medicine and health services research at the David Geffen School of Medicine at UCLA.
The researchers compared the daily use of oral conjugated equine estrogens (0.625 mg) plus medroxyprogesterone acetate (2.5 mg), or CEE+MPA, with the daily use of a placebo pill.
![Estrogen Treatment for Breast Cancer Found to be Good for Breast Cancer]( "Estrogen Treatment for Breast Cancer Found to be Good for Breast Cancer")
Low doses of estrogen may help in the treatment of some forms of breast cancer, a recent clinical study said.
Among the women who did report breast tenderness at the beginning, the risk at one-year was about 1.26 times that of their counterparts on placebos.
Of the women who reported new-onset breast tenderness, 76.3 percent had been on the combination therapy.
Women in the combination therapy group who did not have breast tenderness at the outset but experienced new-onset tenderness at the first annual follow-up had a 48 percent higher risk of invasive breast cancer than their counterparts on combination therapy who did not have breast tenderness at the first-year follow-up.
The study is published in Archives of Internal Medicine.
Source: ANI
ARU
Estrogen Treatment for Breast Cancer Found to be Good for Breast Cancer
Low doses of estrogen may help in the treatment of some forms of breast cancer, a recent clinical study said.
Advertisement
Among the women who did report breast tenderness at the beginning, the risk at one-year was about 1.26 times that of their counterparts on placebos.
Of the women who reported new-onset breast tenderness, 76.3 percent had been on the combination therapy.
Women in the combination therapy group who did not have breast tenderness at the outset but experienced new-onset tenderness at the first annual follow-up had a 48 percent higher risk of invasive breast cancer than their counterparts on combination therapy who did not have breast tenderness at the first-year follow-up.
The study is published in Archives of Internal Medicine.
Source: ANI
ARU
Women and Cancer - Breast Cancer
Encyclopedia section of medindia gives valuable information about Breast cancer in women
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