About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Breakthrough Discovery Could Lead to New Treatment for Alzheimer's

by VR Sreeraman on October 19, 2009 at 12:56 PM
Font : A-A+

 Breakthrough Discovery Could Lead to New Treatment for Alzheimer's

A research team, including an Indian-origin boffin, has made a new discovery that could lead to a new treatment for Alzheimer's disease.

The discovery by researchers from the Mayo Clinic in Jacksonville, FL is based on the unexpected finding that when the brain's immune cells (microglia) are activated by the interleukin-6 protein (IL-6), they actually remove amyloid plaques-considered a hallmark of the disease, instead of causing them or making them worse.

Advertisement

The study was conducted in a model of Alzheimer's disease established in mice.

"Our study highlights the notion that manipulating the brain's immune response could be translated into clinically tolerated regimens for the treatment of neurodegenerative diseases," said Pritam Das, co-author of the study, from the Mayo Clinic in Jacksonville, FL.
Advertisement

Das and colleagues made this unexpected discovery when they initially set out to prove that the activation of microgila trigger inflammation, making the disease worse.

Their hypothesis was that microglia would attempt to remove the plaques, but would be unable to do so, and in the process cause excessive inflammation.

The researchers were surprised to find that when microglia were activated by IL-6, they cleared the plaques from the brains.

To do this, the researchers over-expressed IL-6 in the brains of newborn mice that had yet to develop any amyloid plaques, as well in mice with pre-existing plaques.

Using somatic brain transgenesis technology, scientists analyzed the effect of IL-6 on brain neuro-inflammation and plaque deposition. In both groups of mice, the presence of IL-6 lead to the clearance of amyloid plaques from the brain.

The researchers then set out to determine exactly how IL-6 worked to clear the plaques and discovered that the inflammation induced by IL-6 directed the microglia to express proteins that removed the plaques.

This study suggests that manipulating the brain's own immune cells through inflammatory mediators could lead to new therapeutic approaches for the treatment of neurodegenerative diseases, particularly Alzheimer's disease.

The study has been published online in The FASEB Journal.

Source: ANI
LIN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

Most Popular on Medindia

Blood Pressure Calculator Blood Donation - Recipients How to Reduce School Bag Weight - Simple Tips Color Blindness Calculator Find a Hospital Indian Medical Journals Vent Forte (Theophylline) Sanatogen Post-Nasal Drip Find a Doctor
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Breakthrough Discovery Could Lead to New Treatment for Alzheimer's Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests