About My Health Careers Internship MedBlogs Contact us

Bone Marrow Transplant Helps to Restore Fertility in Animal: Study

by VR Sreeraman on August 1, 2007 at 8:28 PM
Font : A-A+

Bone Marrow Transplant Helps to Restore Fertility in Animal: Study

A new study has confirmed that bone marrow transplantation after fertility-destroying chemotherapy in female mice restores fertility throughout their normal reproductive life.

The study was conducted by a team of researchers led by Jonathan Tilly at Massachusetts General Hospital (MGH).


As part of the study researchers gave adult female mice treated with infertility-inducing chemotherapy bone marrow transplants from non-treated, healthy adult females either one week or two months after chemotherapy.

Both the males and the donor females were black in coat colour while the recipient females were white-coated. As a result, the coat colour of any pups would indicate the source of egg cells used to make the offspring, with tan coats signifying eggs from the recipients and black coats indicating that the eggs had come from marrow donors.

The study found that out of the 10 females that received bone marrow transplants one week after chemotherapy, 9 achieved several successful pregnancies during the study period and all pups were offspring of the recipients.

Additional experiments indicated that resuming mating sooner after transplantation improved fertility rates. When chemotherapy doses were increased to levels expected to cause death in half the mice, those that also received bone marrow transplants had improved rates of both survival and long-term fertility.

The coat-colour results of the mating trial indicated that the transplanted marrow's contribution to restoring fertility did not involve cells destined to becoming fertilizable eggs.

To further investigate this observation researchers gave chemotherapy-treated females, marrow from transgenic females that expressed a green fluorescent protein (GFP) marker only on germline cells, which were precursor cells involved in producing oocytes.

Researchers confirmed that no immune cells from the germline-only GFP strain contained the marker protein, making it highly unlikely that GFP-labelled cells in the ovaries of females receiving germline-only-labeled marrow were anything other than oocytes.

"Right now, we really don't know exactly what it is in marrow that restores recipient oocyte production and rescues long-term fertility. However, we do know without question that immature oocytes can be generated from cells in adult bone marrow, but they are probably not critical to the fertility rescue observed after the transplants," the authors said.

The findings of the study were published in the August issue of Journal of Clinical Oncology.

Source: ANI

News A-Z
News Category
What's New on Medindia
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
World AIDS Day 2021 - End Inequalities, End AIDS
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Ovulation Bone Marrow Aspiration and Biopsy Leucopenia / Leukopenia Infantile Cortical Hyperostosis Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Multiple Myeloma Bone Marrow Transplantation Transplantation 

Recommended Reading
Bone Marrow Transplantation - Animation
Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT)/Stem Cell ....
‘Fishing’ for a Speedy Recovery After Chemotherapy or Marrow Transplant
Researchers at Children's Hospital, Boston, have discovered a novel way of increasing stem cells in ...
Bone Marrow Aspiration and Biopsy
Bone marrow biopsy and aspiration is the removal of some bone marrow tissue for diagnosis and manage...
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Infantile Cortical Hyperostosis
Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the corti...
Leucopenia / Leukopenia
Leucopenia / Leukopenia is a decrease in the number of total white blood cells found in blood. The n...
Multiple Myeloma
Multiple Myeloma caught public attention when model turned actress Lisa Ray, who worked in Deepa Meh...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Ovulation is the time when an egg or ovum is released by female ovary, usually midway during the men...
Organ and tissue transplantation can give a second chance at life to thousands of people. Learn more...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use