About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Body’s Natural Defenses Help Fight Against Klebsiella Pneumoniae

by Hannah Joy on November 20, 2017 at 5:54 PM
Font : A-A+

Body’s Natural Defenses Help Fight Against Klebsiella Pneumoniae

New insights revealed show that the body's natural defenses help fight against Klebsiella pneumoniae, reveals a new study.

The inappropriate or excessive use of anti-microbial agents in past decades has propelled the emergence and spread of multidrug resistant microbial pathogens.

Advertisement


According to the European Centre for Disease Prevention and Control and the European Medicines Agency, each year about 25,000 patients in the EU die from infections with multidrug-resistant bacteria.

Globally, 700.000 people per year die due to antimicrobial resistance.

The rise of superbugs

Earlier this year, the World Health Organization (WHO) published a report on anti-microbial resistance, with a special emphasis on antibiotic resistance of so-called "superbugs". Such bacteria pose the greatest threat to human health due to their resistance to several different antibiotics.
Advertisement

Among these superbugs is Klebsiella, which can cause severe and often fatal infections of the bloodstream and lungs. Klebsiella has been reported to be resistant to common classes of antibiotics and to a great extent also to carbapenems, the last resort to treat severe nosocomial infections.

Treatment options beyond common antibiotics

The researchers around Pavel Kovarik at MFPL and Jose Bengoechea at Queen's University Belfast now discovered how immune cells arriving at the site of infection communicate and join forces to eradicate Klebsiella during lung infections. Their study suggests that future therapies of severe Klebsiella infections could target the immune system, rather than the pathogen itself.

Natural killer cells keep bacterial growth in check

The scientists report the mechanism of how natural killer cells, important cells of the innate immune system, control the growth of Klebsiella during lung infection.

Klebsiella induces critical immune response regulators, type I interferons (IFNs), which act as middlemen in the crosstalk between alveolar macrophages (immune cells that engulf and "eat" microbes) and natural killer cells. Type I IFNs help activate natural killer cells, which in turn license macrophages to launch an antibacterial program.

"Type I IFNs are used by the immune system to transport messages between immune cells to orchestrate a perfect defense. Natural killer cells represent the conductor of the defense orchestra, whereas macrophages are the bacteria-killing instruments," explains Masa Ivin, first author of the study and PhD student in the Kovarik lab at the MFPL.

Pavel Kovarik and his team are optimistic that their new found results will contribute to the development of urgently needed novel therapeutics against multidrug resistant pathogens.

"If drugs fail to kill the pathogen, we should help the immune system do the job. Our current study identifies new and feasible ways how to support the immune system in fighting superbugs."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Canadian Researchers Develop World's Most Sensitive Test to Spot Superbugs
The newly developed test method can pick up any compound that might signal the presence of ......
Better Use of Antibiotics Could Help Fight the Superbugs
Proper use of antibiotics could help fight the infection Clostridium difficile - the superbug. ...
Researchers Identify New Ways to Prevent Toxicity of Superbugs
Researchers have identified a new way through which the toxicity and virulence of the notorious ......
Spread of Potential 'superbugs' Understood Better
A new study has found a link between the annual human pilgrimages and the spread of ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)